+39 0331 1693557
inti@intisrl.it
Download of all our available used machinery
The F2000 is a machine with linear transport with intermittent motion, for distributing liquid solutions in cylindrical containers. The machine is particularly suitable for the distribution of aseptic products, as it can operate in both conventional clean rooms and isotechnics.
The bottles are fed by means of an upstream feeding belt that introduces the bottles into the infeed starwheel.
Once the bottles have reached the infeed starwheel, they are positioned on the toothed belt on which the antistatic polyethylene moulded plugs and polyethylene contrast guides for positive linear transport of the containers are inserted using a 'quick-fit' system.
The dosing of the bottles takes place during the conveyor movement, the filling system is carried out by an external unit with 8 Felxicon peristaltic pumps, which performs the filling of the bottles by synchronising with their movement.
Once the bottles have reached the outfeed star, they are positioned on an in-line or 90° exit conveyor with independent drive controlled by an inverter.
The machine is equipped with a rejection station on a motorised belt with application of suction cups and vacuum on the exit starwheel for the bottles AND with a device for checking the actual rejection of the container.
COMPLETE SYRINGE FILLING LINE OPTIMA GROUPS • 2007
1. Debugger machine Bausch&stroebel model LFO 9060 from 2012
2. Belt under laminar flow Optima Inova
3. Robot for Tyvek removal Optima Inova model TRR •
4. Filling machine Optima Inova model H6-10
5. denester machine Optima Inova model SH260
6. inspection machine Brevetti Cea model k15\600 •
7. Renester machine Optima Inova model SN260 •
Syringes diameter 10.85
speed 400 pz\min
FSV 1111 - Colanar Innovative Solutions is designed for filling syringes in the pharmaceutical field.
- Insertion of the syringe into the nest holder by the operator
- Process start via HMI Touch Screen
- Automatic positioning of the syringe
- Washing the syringe with nitrogen before filling
- Filling /inserting rubber stopper with vacuum capping
120 Volts
Technical specifications
◦ Output: up to 25 / min
◦ Filling range: 50μl to 20 ml
◦ Range:
◦ 0,5 - 20 ml nested syringes
◦ 2 - 20 ml nested vials
◦ 1,5 - 3 ml nested cartridges
The machine is set up for syringe of 160 unit trays of 1 ml with 2 different filling system
Technical Data
Output: Up to 25 syringes/ min.
Filling Range: 50 μl to 20 ml
Dimensions: Approx. 1020 mm x 1200 mm x 1940 mm (40” x 47” x 76”)
Working height: 930 mm (37”)
Weight: Approx. 500 kg (1100 lbs)
Power: 120V, 60 Hz, 20A
Controls: Panasonic PLC, Servo Drives, and HMI
Finish: All surfaces Stainless Steel and Plastics
Utilities: Varian Vacuum Pumps (included)
Compressed Air: 4 bar (60 psi), 85 l/min (3 cfm)
Complete line for ampoule Bosch 24.000 per hour with Isolator from 2009 Composed of :
1) Ampoule filler under isolator
2) Depyrogenation owen for ampoules Bosch
3) Ampoule washing machine with different washing cicles
4)Air Handling Unit
1-Ampoule filler under isolator • Producer : Bosch • Model : ALF 4080 Year of manufacture : 2009 • Production : 400 ampoules per minute working range • Diameter : From 9 up to 30 mm • Height : From 60 up to 160 mm • Formats incluided :1 - 2ml • The machine comes with ISOLATOR and DEDICATE AHU AND CIP/ SIP IPC ( weigh control ampoules ) • The ALF series of machines meets all the prerequisites for modern ampoule production. The convincing line concept. • Wide experience, state-of-the-art know- how, highly developed engineering and Bosch quality – new dimensions for dependability, economy and flexibility with easy operator control. • The ALF series was configured in accordance with pathfinding, pharmaceutically compliant findings to provide a modern, ergonomic design that supplies the customer with maximum benefits. Decisive in this design is a basic ma-chine that can be equipped and retrofitted with various equipment units. These include: • In-process control system • Infeed and outfeed starwheel • Isolator version Work and production considerations: • Easy operator control due to the slim, tidy, clearly laid-out construction Easy cleaning. • All machine functions can be overseen, controlled and operated from one position at the front. • Clean Room compliance. • Drive and production segments are clearly separated: worktop right through. • The ampoules are transferred directly from the sterilizing tunnel to the ALF infeed belt. • Via a scroll conveyor and transfer wheel the ampoules reach the conveying system by means of which they are con-ducted through the work stations: gasflushing, filling, sealing. • Each filling point controls individually contactless scanning of the ampoule necks – "no ampoule – no filling". The ampoule necks are precentred by the draw-off grippers, the ampoule tips are then grasped and fed into a collection container. • During the sealing procedure post-gasflushing can take place. The filled and sealed ampoules are pushed virtually load-free into the outfeed magazine. Rotary slide pumps: • Bosch provides precision filling for parente- ralia with its proven rotary slide pump. Product- conserving and drip-free filling to the highest degree of filling precision are ensured for a wide range of different properties. • Bosch seal-free rotary slide pumps have easy vertical cleaning paths. Technical in the lead: • 3-part: rotary slide valve, pump cylinder,Pump piston. • Seal free. • Easy, vertical cleaning paths. ❒ • CIP/SIP capability. 2) Depyrogenation owen for ampoules Bosch Producer : Bosch Model : HQL 2440S Year : 2009 Production : 24.000 ampoules of 1 ml per hour HQL facilities are ideal for vial sterilization. This model is exceptional due to the lack of passage in the tunnel, which is the result of the laminar hot air flow process with its high degree of efficiency. Sterilization tunnels are used in pharmaceutical industry filling lines to sterilize glass containers before aseptically filling them. These tunnels use forced air at temperatures up to 350 °C. Bosch HQL drying and sterilization tunnels operate with unidirectional flow, with process curves of temperature progression and significantly reduced sterilization times. They guarantee the consistent precision necessary for validation, qualification, and reliable production capacity. Through a filter, the make-up air is introduced into the tunnel. Inside the tunnel, the air, drawn in by the fans, feeds the supply and cooling section through the pre-filters and the air particle filters in the separate areas of the tunnel. Using the laminar flow principle, the air flow is directed vertically in the containers. Below the conveyor, the air is directed back through a recirculation duct to the fan. The fans need fresh air for the heating section: laminar flow unit. The heating elements in the recirculation duct serve to heat the recirculation air to the preset temperature. Below the particulate air filters are heating elements that are output to a recording and temperature control device. The cooling section works with laminar flow. A fan in the cooling section draws the hot air under the conveyor belt. The volume of exhaust air is adjusted automatically. The tunnel is equipped with an automatic overpressure control in the cooling section. Modular system for tunnel assembly suitable for the required power range with optimal energy consumption. Construction according to GMP. Compatible container transport systems for stable and non-stable containers. Safe conveyor belts on the floor and side levels operated simultaneously. Excellent accessibility and ease of operation. 3) Ampoule washing machine with different washing cicles (water WFI - sterile air ) Producer : Bosch Model :RRU 3084 Year of manufacturing :2009 Production : 400 ampoules per minute Working range : Diameter : 9 - 30 mm Height : 60 - 145 mm Formats included : 1 -2 ml The Bosch RRU series of washers and dryers perform ultrasonic cleaning for fast and accurate removal of particulate matter. Its swivel design allows for a small footprint and ease of operation with fast and accurate removal of particulate matter and reliable feeding of small containers. RRU Bosch rotary heads will give you excellent results with gentle vial handling. They can be configured for a wide range of formats. Rotary washer ideal for cleaning vial bottles. Exceptional for its optimal accessibility, for example, and it is very easy to use. Processing ranges and capacities depend on individual containers, line integration, etc. Construction according to GMP; reduced size; safe transport of containers; high level of ultrasonic cleaning; stations for internal and external container washing; with the pumping station; fast format change.
NEW Bausch ATG Liquid Filling Line under Isolator. Never Used. Ready to be shipped and installed NOW.
With 12 Months of Warranty + Commissioning Service.
Ready to be shipped and installed NOW.
SPEED
2R - 9900/hr (165p/m)
6R - 6600/hr (110p/m)
Change parts available up to: 30R - 30,000/hr
Bausch ATG – Filling Line
• Machine 1: Bag, Lid and Line Remover
• Machine 2: Debagging station
• Machine 3: PUV light tunnel type 411
• Machine 4: Delidding machine
• Machine 5: Filling and stoppering machine type 534 - change parts available 2R/6R
• Machine 6: Crimping machine type 551 – change parts available 2R/6R
• Machine 7: Outside file washing machine type 309 – change parts available 2R/6R
• Machine 8: Labelling machine type 6034 (with dual tray discharge)
• Machine 9: Viable and non-viable monitoring system
ESCO GB LTD - Isolator
• Machine 1: Isolator + oRABS
• Machine 2: De-Bagging oRABS
• Machine 3: De-Lidding Isolator
• Machine 4: Filling and Stoppering Machine Isolator
• Machine 5: Crimping Machine Isolator
• Machine 6: Outside Washing Machine Isolator
• Machine 7: Glove Testing Units
• Machine 8: Glove tester
with following documentation:
• FAT Documentation
• SAT Documentation
• Installation Documentation
• Videos / Photographs
• De-commissioning Documents
• Quotations
• Layout Drawings
• Equipment Package
• HAZOP
• IQ OQ Documents
• Delivery Documents
• DDS
Filling and capping machine model FSP1 CORIMA MARCHESINI
Total mass of the machine. 650 kg
Power of electrical system in kW. 400V
Electrical installation
Main power supply: 400V
Fasi 3F+N+T
Frequency 50 HZ
Set power 2 kW
Air pressure 0.5%bar
Recommended temperature for the working environment 16°÷35°.
Fluids:
Nitrogen pressure 6 bar 5%
Nitrogen connection Ǿ 8mm quick connection
Products currently available
Working format:
Syringe Ǿ 10.85 mm Production rate: 2000 und/h
NEST DE 160 DE 1 ml Diameter 8.15 mm
NEST DE 100 DE 1 - 3 ml
NEST DE 64 DE 5 ml
Bosch MLF 3002 intermittent motion filling and closing machine for injectable vials. Includes rotaty table for empty vials, 4 rotary piston filling heads (currently filling 100ml), stoppering inserter with bowl feeder, and closing system for ALU caps with bowl feeder. 90 degree reject to the rear of the machine, and product discharge in line with product flow. Suitable for containers up to 55mm diameter and up to 185mm high (double index), inserts and caps up to 36mm diameter.
Output approximately 6,000 containers per hour.
Automatic Syringe Filling and Closing Machine Type Inova SV 122 V
Technical data
Output*:
Up to 4,500 syringes/h - infinitely adjustable.
*Output depends on syringe size, dosing volume, viscosity and other characteristics of the filling product
Syringe size range:
nested 0.5 ml to 20 ml HYPAK syringes of all leading syringe manufacturers with the corresponding nests and tubs
Dosing range:
0.2 to 29 ml, depending on the selected pump size; multi-filling possible
Dosing accuracy:
0.2 to 0.6 ml srel = ± 1,5 %
0.6 to 1 ml srel = ± 1,0 %
higher than 1 ml srel = ± 0,5 %
Machine finish:
Total exterior made of stainless steel (AISI 304) for easy cleaning, flanges upon machine table top made of anodized aluminium.
Safety regulations:
In accordance with Prevailing Safety Regulations for packaging machines and auxiliary equipment. Meets or exceeds OSHA regulations
Surface finish:
All machine parts in contact with the product are finished in stainless steel 316 L. The parts above the machine table are of anodized aluminium, synthetic material and stainless steel AISI 304.
1 stopper inserting station for plunger stoppers, consisting of:
- complete stopper inserting station with cam-controlled synchronous insertion movements for insertion tube and insertion rod
- the stopper insertion depth is adjusted by changing
the height of the work table
- 1 sorting drive for sorting bowl Ø 250 mm,
substructure attached to the machine
- Min. accumulation sensor at the outer stopper supply rail - 1 linear vibratory drive
for stopper infeed
SYRINGE INCLUDED
Filling and capping machine: Groninger. Model KFVG 251 from 2008 (part of a 23-1123 Washer + Tunnel + Filler line)
MAR Model M39-4R-2S-2A Liquid Filling Machine, 460V, model M39-4R-2S-2A, is manufactured by Machine Automache Riempitrici (MAR).
The M39 is a double pitch monobloc machine, which provides dosing and capping operations by moving two cartridges per time, up to 120 p/minute. The machine is suitable to handle cartridges from 0.5 to 10 ml. Cartridges loading and unloading is by means of compact in-feed and out-feed trays
Bearing Base
This assembly as the name implies is the load-bearing structure of the machine, so it supports the container processing stations, transfer and transport systems, and safety doors.
Container Feeding
Consists of an independently driven belt designed to maintain a constant and continuous flow to the machine.
Filling station
This consists of a station made up of 4 filling nozzles that allow the machine to refill 2 containers at a time, dividing the filling amount into 2 consecutive doses. The filling station is directly driven by the main motor drive of the machine .
Filling dosing unit
It consists of a distribution manifold for the filling liqiudo and 2 nozzles applied to the filling station
Capping station
This is a station consisting of 2 capping heads that enable the machine to pick up the caps and subsequently place them on the container performing capping. The capping station is directly driven by the main motorization of the machine .
Caps feeding
The system consists of a vibration orienting unit and a cap transfer unit.
Rejection of unsuitable containers
The rejection of containers deemed unsuitable for the required quality standards is implemented by means of two pneumatic cylinders used to unload the containers into the 'waste accumulation drawer .
Discharge of suitable containers
Containers that are deemed suitable for the required quality standards are continued and thanks to a guide are deposited on the belt at the machine exit .
User machine interface
It is located on the front side of the machine and contains the machine management and control commands .
Main : 380 v - 50 Hz - 3F + N
Auxiliary : V24
Installed electrical power : 5kw
Operating pressure 6 bar .
- Bearing Base
This assembly as the name implies is the supporting structure of the machine, so it supports the container processing stations ( nitrogen flushing, filling, sealing ), transfer and conveying systems, and the safety cabin.
- Machine motors
This group includes the electric motors, gears and all mechanical parts used to transmit motion to the various machine components.
- Container Feeding
This group consists of a conveyor belt and screw conveyor, driven directly by the main machine motor.
- Nitrogen flushing stations.
This group consists of 2 nitrogen supply manifolds and special needles for introducing gas into the containers. All this is used to ensure filling and sealing of containers in a modified atmosphere.
- Filling station
This unit consists of an accoption of 6 product distribution syringes and 6 filling nozzles .
- Sealing stations
This group consists of 2 subgroups, a container preheating group and a sealing grup po. Both groups use burners fueled by high-pressure I oxygen gas.
- Container discharge
This unit consists of a container handling pad and an accumu lo drawer.
- Electrical panel and electronic management
A single electrical panel encloses all the control components, there is also an opera toor panel from which all the operations necessary for running and managing the machine can be carried out.
- Laminar flow hood
Ventilation device capable of generating a unidirectional and vertical air flow.
Performance :Maximum achievable speed : 12000 Containers / hour
Power and consumption :
Primary : 380 Vac - 50 Hz - 3 F + n
Auxiliary : 24 v
Installed electric power : 3 kw
Working pressure : 6 bar
Fully automatic syringes (injectors/sterile area) - filling and closing system NORDEN BIOFILL 3000,
70 syringes/min, speed adjustable,
VA version, for plastic injectors 7/10/20ml, accuracy +/-0.5%, volumetric filling pump ,
Filling: liquid/viscose/ointment,
Composed of:
control panel, control cabinet, syringe feed station, filling station & closing station, dosing pumps, sorting drum, test stations, storage tanks, conveyor belts, elevator,
working height 900 mm +/- 50mm,
380V, 50Hz, 3Ph,
air supply 5b,
Syringe filling and sealing machine (injector/sterile area) KUGLER FVA 101,
max. 4200 pcs/h
dosing range 3-26 ml
accuracy +/-0.5%,
filling: liquid/viscous/ointment,
formats: 10/20 ml,
closing station, plastic injectors, dosing pumps, sorting vibrator, feeding station, individually transported to work stations in cycles, test stations, storage bunker (200Lt, for approx. 1500 injectors, 380V/50Hz, 3-Ph,
working height 900 mm +/- - 50 mm, 1500 kg (Kugler),
POP 1 FFS 3000 Filling Machine
BRAM-COR POP2 (specific for bags with tubes) and POP1 (specific for bags with connectors) machines use PVC-Free films and are designed to produce bags for injectable solutions, in sizes from 50 ml up to 5000 ml. They actually transform a PVC-free film into a finished, filled, sealed and printed infusion bag.
The POP 1 FFS 3000 forming/filling machine is designed and manufactured with materials in accordance with CGMP and FDA standards, meeting the specifications outlined in current pharmaceutical regulations;
- All welds were performed using TIG technology
- All seals installed on the filling unit are made of soft sanitary grade TEFLON
Discharge of the bags onto the conveyor belts
The bags continue their travel until they stop (in groups of 4) in front of a second slide, which, by means of a pneumatically controlled movement, ejects them from their housing on the evacuation porter
In case one or more bags escape the ejection system, a mechanical extractor, in the return phase of the evacuation porters, intervenes on their forced extraction
Bag drying tunnel:
This station picks up the freshly filled bags, provides for their drying, and takes them to a series of conveyor belts that, in turn, direct the bags to the various storage stages.
When the operation of heating and cousing the connectors is finished, the “R” resistors move back upward, allowing the 2 “MC” vices to weld the still superheated connector spout
Coolant is passed inside the 2 vices, which, in addition to preventing the connector beak from sticking to the vices, allows the immediate solidification of the beak itself
Pouch connector soldering:
Before starting this operation, the bags are emptied of residual air by pneumatically pushing the “BS1” bar
The “BS1” bar is kept under pressure on the bags while a series of “R” resistors descend toward the connector beaks suitably clamped by the corresponding pneumatic clamps “M”
Bag pickup from the forming machine:
The bags arrive at the pick-up station (arrow 1 in the figure) and here, in groups of 4, they are pulled off the relevant advancing flights by means of an extractor “A” (arrow 2 in the figure) that provides for their subsequent engagement on a second set of flights “B”
Vibrating tank feeding:
Connectors are manually loaded inside the two vibrating tanks “V” and “V1” that feed the loading unit “B”
Connector placement:
V1
Each individual connector is brought to the vicinity of the pick-up sled which provides for the input and positioning of 4 connectors at a time, 2 coming from vibrating tank “V” and 2 from “V1”
Automatic loading of connectors an:
This station allows the automatic loading of connectors onto the feed carriers, the only operation that the operator has to perform manually is to continuously restore the correct level of bulk connectors inside the 2 feed vibrators positioned at the sides of the loading station itself.
Empty bag pickup:
PHARMACEUTICAL EQUIPEMENT
At this point, the bags continue their journey to the “BL” picking station (see figure below) from where they are subsequently transferred to the filling machine
Bag cutting and separation:
The step-by-step advance of the “PG2” gripper brings the film with the bags still joined under the “BCU” cutter
Formed bag cooling:
Coming out of forming, the now formed bag “B” goes under the cooling press “BC”.
During this stage 2 pneumatically controlled “CP” cooling molds compress the 2 films “P” by cooling them together with the corresponding connector “C”
Bag forming:
The 2 films “P” and connector “C” are brought, by the stepping feed unit, to the forming press “BF”.
During this stage 2 heated “HP” molds, pneumatically controlled, compress the 2 films “P” by welding them together with the corresponding connector “C”
Voltages: Main: 380V 50Hz Auxiliary 24V DC Powers Main 35Kw Prod: 2000 S/H
Via XXV Aprile, 8
21054 Fagnano Olona (VA)
Italia
Tel. +39 0331 1693557
email: inti@intisrl.it
