+39 0331 1693557
inti@intisrl.it
Download of all our available used machinery
MAIN FEATURES OF STILMAS PSG-DTS
Instant start: pure Steam is immediately available thanks to the design of the"Accumulator boiler"technology. The unit can switch from standby to full capacity in seconds
High flexibility: the production capacity can be automatically varied from 0 to 100% according to the request
Unique purification system: gravitational purification principle for better vapor purity guarantee
High quality Steam: the quality of steam produced is constant in terms of pyrogen content, heating value and drying fraction, regardless of pressure and production scope
Simple and clean mechanical construction: the decontamination chamber without baffles or defrosters, ensuring the best inspection capacity, minimizes the risk of corrosion, for the longest expected life of the equipment.
Extremely limited maintenance. Absence of moving parts, expansion joints or mechanical seals
Compact construction and low height. Little extra head space is needed for disassembly and inspection.
PRINCIPLE OF OPERATION
The design of STILMAS PSG-DTS pure steam generators is based on the technology of the radiator. The system consists of two parallel bodies: the heat exchanger and the evaporator/decontamination column. The feed water is fed to the decontamination column (main body) while the industrial steam is fed to the supporting side of the heat exchanger. Industrial steam heats the feed water to the evaporation temperature, creating a strong circulation within the two bodies.
The Steam develops in the evaporator where its low speed and the height of the decontamination column eliminate any possible entrainment of impure water droplets. A pressure transducer, installed in the evaporator, controls the ingress of industrial steam to the heat exchanger, thus ensuring a constant pressure of the pure steam produced. Supply water flow
it is controlled by a level transmitter installed in the evaporator.
REDUCTION OF NON-CONDENSABLE GASES (NCG)
Stilmas has developed two alternative solutions to meet the NCG requirements of EN 285.
The first solution consists of an intermediate tank in which the preheated feed water is sprayed by separating the liquid from the gas which is then extracted outside.
This solution can adapt any clean steam generator to allow the NCG content to be achieved.
The Second Solution, Stilmas Gasbuster ® , is integrated into the PSG. The degassing process occurs when the preheated feed water enters the decontamination column and is sprayed by separating the liquid from the gas which is then extracted by a small stream of clean steam.
With both solutions, Stilmas PSG can deliver much lower NCG content than required by international standards.
CONSTRUCTION FEATURES
The system is entirely made of AISI 316L stainless steel. the standard finish of the active surface is smooth and flush with passivation; mechanical or electrochemical polishing can be performed on request.
The heat exchanger is of casing and tube type with double sheet metal execution; the tubes expand on the plates, avoiding any welding for a totally hygienic execution, and a better resistance to expansion efforts.
The design and construction of the decontamination chamber, which is a completely empty column, ensure the best inspection ability. The absence of welds in this area drastically reduces the risk of corrosion, for a very long service life of the equipment.
The overall design of the building, together with the decontamination process described, ensure a very compact design and require extremely limited space for maintenance.
400V, 50 Hz, ph: 3+N+T
The packaging line consists of 4 segments:
Blister machine 1/2 : length: 2590 mm-height: 1700 mm / depth: 1400mm /
Weight: approx. 3,800 KG
Blister machine 2/2: length: 3720 mm / height: 1700 mm / depth: 2500 mm /
Weight: approx. 4,000 KG
Adapter feeding range: length: 2600 mm / height: 1700 mm / depth: 1400
mm / Weight: approx. 600 KG
Cartoning machine: length: 3300 mm / height: 1700 mm / depth: 1400mm /
Weight: 4,000 KG
Total length: approx. 12210mm
Power supply: 230 / 400 V / 3Ph
Rated current: in line 95.4 A
Connected load: in line 63.8 KVA / 24 V (DC)
Operating pressure: 7-8 Bar (cut-off limit 6.5 bar)
Technical Data
CP 1200 (blister machine)
Sheet: width: max 306 mm
Roll diameter: max 800mm
Diameter of roller core: 70-76mm
Forming picking length: 180-285mm
Max sealing surface: 285mm
Technical data:
Cartoner P3000
Format range: length of support (depth) 65 - 150 mm
Folding width: 35 - 85 mm
Dimensions: 12 - 95 mm
Rudolf Deckert AVM 730 capper
Intermittent rotary capping machine with 12 stations
Plastic capping head and metal caps
Automatic caps rotary feeding
Speed up to 4200 bottles per hour
Diameter up to 90 mm
Height from 40 to 215 mm
The dry sterilizer oven DS 100 is used for the sterilization and depyrogenization of empty glassware or other glass or stainless steel packaging or containment material so that it can be introduced into a sterile room.
After the sterilization cycle, the material is therefore discharged from the passage door of the sterile rooms. Being the filters placed at the exit of the sterilization Chamber, of the absolute type filters with cold efficiency of 99.998 DOP method, during sterilization, the air circulating inside the trolleys is air in class 100. The filters used for this purpose are filters that continuously withstand a temperature of 240 degrees centigrade and therefore allow both dry sterilization and depyrogenation.
During all stages of treatment, inside the furnace, the pressure is constantly maintained positive with respect to the external environment. After the automatic sterilization cycle, the shutters all close to isolate the oven from the outside while the ventilation continues to work to maintain the internal overpressure ensuring that the material is not contaminated.
Sterilization time: 60 min for temperature 220 C while 75 min for temperature 200 C.
Cooling time to be set around 120 min.
See for the use of timers the attached instructions taking into account to always set the MODE "A" and the value in MIN. The cooling time should be selected according to the experience resulting from the type of load used and the temperature of the sucked air.
Complete line for the packaging of pre-filled syringes as follows:
- De-Nester Corima model MPT100L
- Corima AEC212 Syringe Labeler and Plunger Inserter with Plunger Unscrambler and Label Easy-Splice
- Marchesini FC420 thermoforming machine for pre-filled syringes with feeding system.
- Horizontal intermittent and continuous motions cartoner for tray packs or thermoformed trays FlexaASB (for ampoules, vials, syringes)
- Cartoning machine MARCHESINI GROUP MC 820
Technical data sheets of each machine to be download through the link above.
This is a fully automatic, intermittent motion Blisterpacking machine with a capacity up to 50 cycles per minute. The maximum output is 200 Blisters per minute depending on blister size.
The machine is of ‘balcony construction’ - all relevant stations are individual modules, which are cantilevered off a large aluminium plate that forms the front of the machine housing. The remainder of the machine cabinet is constructed from fabricated steel and houses the drive unit, gear trains, chain drives and the electrical control equipment.
PVC, PVC/PVDC, PVC/Aclar film is drawn from a reel and is first heated and softened and then deep-drawn in the blister forming station. The blisters are formed in the mould with the aid of compressed air – the web is then pulled forward, up and across the feeding area where the blisters are filled with product.
The filled blisters now pass into the sealing station where they are covered with aluminium top foil which is drawn from a reel mounted above. The heated top sealing plate on this station incorporates coding digits to allow a code to be embossed as the blisters are sealed. Air- operated grippers then pull the web forward through a short cooling plate before they are cut out from the web.
The web now passes into the guillotine cutting station, where the blisters are cut out and discharged down a chute where they can be collected in a suitable container.
All operator controls are located in a console on the right hand side, including the thermostats and temperature gauges. Two interlocked, large sliding Perspex doors protect the operator from the moving parts of the machine. At the rear of the machine cabinet there are hinged doors for easy access for cleaning and maintenance purposes.
TECHNICAL SPECIFICATIONS:
Maximum capacity : 50 strokes/min with 10.0 mm draw-depth 35 strokes/min with 16.0 mm draw-depth
30 strokes/min with 18.5 mm draw-depth
Maximum forming area :110 x 150 mm
Maximum foil width :170 mm
Max. Ø PVC roll :400 mm
Max. Ø aluminium foil roll :240 mm
Power consumed :5.0 kw (average)
Total connected power :8.0 kw (peak consumption)
The machine requires an external supply of compressed air and a chiller unit to be connected – we can offer a suitable chiller unit at extra cost if required.
The monoblock F87 is an automatic intermittent movement machine that can perform three operations at the same time: a volumetric filling and two closures. Aqueous, alcoholic, sugary, foamy, viscous products can be given. Droppers, glass or plastic pipettes, nebulizers, normal or freeze-drying rubber caps can be introduced. You can apply screw caps, press caps, ferrules, PFP etc. The carter and the machine table, on which all the operating groups are fixed from the inside, are in AISI 304 stainless steel and protect the mechanical parts from the infiltration of the treated products and the water used for washing. The operating units and their supports are made of AISI 304 stainless steel and receive their motion from a single variator motor, obtaining the dual purpose of relating, without interruption, the speed of the machine with the rotation speed of the screwing or seaming, and not to have electric motors above the work stations, thus eliminating sources of possible pollution of the treated products. The volumetric filling unit is also located on the machine - plane and the syringes (in glass or stainless steel) act vertically. This solution avoids the radial stresses that are often the cause of breakages, reduces wear, and facilitates the adjustment and cleaning of the filling units. The closing groups are designed to process all types of caps or caps commonly used in the chemical, pharmaceutical and cosmetic industries and have simple and easy adjustments that reduce time for format change. A peculiar feature of the group for the introduction of caps or droppers is the ability to rotate the closing element during the introduction phase. The advantages of this system are manifested especially with soft rubber stoppers which, if introduced without rotation, tend to come out of the bottle. The screwing of the capsules takes place in two stages: a spindle picks up the capsule, brings it to the bottle in the correct position and gently pre-screws it. At the next station, a screwdriver tightens it respecting the desired tightening torque. The vibrating feeders of the closing elements are positioned at about 1200 mm from the floor, so the operator has no difficulty in checking and supplying them.
The machines and lines of the SFM series are designed for processing nested containers such disposable syringes. The dosing station is designed to process liquid products using rotary piston pumps. Depending on machine type and equipment, nests are supplied manually or fully automatically. Filling and closing are always fully automatic. The machines are also designed for vacuum-assisted dosing and insertion of plunger stoppers. This virtually eliminates entrapped air when filling disposable syringes with pharmaceutical product.
One used Vector Hi Coater
Model HCT MINI
Stainless steel construction
8" diameter x 4" deep perforated pan with baffles
4" pan opening
40-watt pan motor, with main blower, pre filter and post filter housings
FOD ovens, such as autoclaves, run batch processes and are the ideal solution for the sterilization of all those production lines in which the variability of products, batches and formats do not allow the use of continuous sterilizers such as tunnels. FOD ovens main advantage lies on its particle contamination class assurance. Fedegari guarantees the contamination level to remain under the established standards values for 100 class. This accuracy is verified also during the most critical phases such as heating and cooling, when the thermal expansion of the filters may release a great amount of particles. Particulate contamination control originates from complex fluid dynamic studies and a close collaboration with Camfil, the world’s most respected filter manufacturer, with whom Fedegari works at the development of high-temperature filters. DESIGN & TECHNICAL FEATURES
• Sterilizing chamber: sealed welding, made of AISI 304 stainless steel 1,5 mm thick.
• Single-leaf flush door on both sides, internal surface in AISI 304 stainless steel.
100 mm thick rock-wool panels guarantee perfect thermal insulation: average temperature of 40 °C on the external surfaces at operating temperature of 250 °C.
Electric heating through AISI 321 stainless steel heating elements, assembled on a sliding frame for easy removal and maintenance.
• Cooling by AISI 304 stainless steel heat exchanger.
• Continuous automatic control and regulation of pressurization of the sterilizing chamber.
• Continuous filtering of air in the sterilizing chamber, thanks to a system composed by 4 HEPA filters.
• 5 RTD PT100 temperature probes.
• Safety thermometer on non sterile front to prevent door opening if chamber temperature exceeds set value.
• Stainless steel port for validation probe positioned on not sterile side.
Closed and open ampoules filler Cioni A6FC
Manufacturer Cioni
Modello A6FC
Automatic filling machine for closed and / or open ampoules with automatic loading and unloading. The machine automatically loads the ampoules 6 by 6, turns them upside down, opens them, turns them over and fills them with 6 syringes and seals them, unloading them on a tray.
All these operations are carried out with a single operator. The machine also works for open blisters.
Formats included for 1-2 ml
The equipment comes with its laminar flow
Technical data:
Hourly production: 12,000 units.
Maximum diameter of the vial: 19 +/- 19.5 mm
Dosage: 1 +/- 10 ml.
Feed to load: width max. 310 +/- 315mm - width min. 160mm - length max. 500mm
Discharge: width max. 365mm - width min. of the individual basket 160mm - length max. 500mm
Machine measurements: width 2300 x length 1940 x height 1600 mm
Net Weight: 460KG
Gross Weight: 780KG
Installed potency:
220-380V 50Hz Absorption A. 220V A. 6.5 - A. 380V A. 4.2
Pressures:
G.P.L. min. Kg / cmq. 0.6 - max. Kg / cmq. 2 +/- 3
Oxygen min. kg / cmq. 1 - max. kg / cmq. 3
Nitrogen min. kg / cmq. 0.4 - max. kg / cnq. 1.2 +/- 1.3
Complete line for sterile vials composed of:
Washing machine
Manufacturer INOVA
Type VWM-C
Year 2007
Electric 230/400/50Hz/29A
sterile tunnel
Manufacturer INOVA
Type SHT-C
Year 2007
Vial filling & closing machine
Manufacturer INOVA
Type VFVM231
Year 2007
Electric 230/400V/50Hz/ 20A (protection)/3A(power)
Details: pre/filling/after gassing station
Capacity for vials R2/R6/R8 approx. 1500V/h
Capacity for vials R10 approx. 1300 V/h
Capacity for vialsR50 approx. 400V/h
This pharmaceutical grade bottle washing machine has been designed to meet the needs of the most demanding customers and to comply with international standards in order to provide high level performance along with easy access to components, all in a small footprint. This rotary washing system was developed and designed keeping in mind the high level of cleanliness required in the pharmaceutical industry. High washing and rinsing performance. Small footprint, size and utility consumption. The washing chamber is made entirely of stainless steel and is surrounded by a Plexiglass cover. Presence of an electrical panel for easy control management.
Condense Capacity 500 kg
Features Multi format vials
Shelf area 3.34 m²
Chamber volume 11500 L
Quantity of Shelves 18 + 1
The Dimensions of the Shelves are stated To be 136 x 198 = 2,69 sqm each shelf
The Usable Shelves Area Will be 2,69 x 19 = 51,11 sqm
Lifting System of Shelves Hydraulic
Lifting Capacity 30 tons at 200 bars
Space between shelves 83 mm
Chamber Height 2950 mm
Chamber Depth 1685 mm
Chamber Width 1982 mm
Type of Cooling Nitrogen
Sterilization and DE-icing By steam
CIP (Cleaning in Place System) YES
Operating System In the past windows XP and now emulator
PLC System Rockwell PLC
2 Cascade of Compressor First stage refrigerates and Second stage freezes up to minus 65
Freon Type Freon R23 and R410
Vacuums Pumps 2 (The model is Alcatel 2100)
The Capacity of the Vacuums Pump
Booster Pump 1
Year of Decomissioning Beginning 2018
Weight of the Lyo Appro. 60 tons
Equip with SCADA +11A4
SCADA Falcon System
Freezing system hybrid with compressors and liquid nitrogen
The liquid nitrogen system is used as a backup in case thecompressors fail so the vials batch can be saved
Silicone oil of the lyo. This oil has been drained during the decommissioning of the equipment
There is a system called “Pneumatex” that is part of the equipment. It prevents air to enter the chamber (it is an expansion tank)
Door One Door
Loading Manual Loading, from tray with rods
Cleaning of Chamber Automatic cycle with steam
Manual Cleaning With an ACP bellows, conventional cleaning, clear kens water, IPA
Automatic stoppering System
Via XXV Aprile, 8
21054 Fagnano Olona (VA)
Italia
Tel. +39 0331 1693557
email: inti@intisrl.it
