+39 0331 1693557
inti@intisrl.it
Download of all our available used machinery
- INFUSION SOLUTIONS PRODUCTION PLANT
- This is a facility designed for the preparation of infusion solutions consisting of a room containing 4 tanks fed by the produced water and equipped with systems for the recirculation and mixing of the solutions. The plant is fully computerized and managed by an electronic control system. The produced solutions are introduced through a “solution transfer line” into the plant for the filling of the bags.
- N.3 5500 liters REACTORS
- Manufacturer: BRAM- COR
- Model: DISS WSCP 5500
- Testing Agency: BUREAU VERITAS
- Factory No.: 1309
- Year: 2002
- Weight: 2500kg
- Capacity: 6116 liters
- double jacket 424 liters
- Max. operating pressure: 3 bar (body side) 1bsr (jacket side)
- Maximum operating temperature: 143 °C (body side) 121 °C (jacket side)
- Hydraulic test pressure: 5bar (body side) 1.7 bar (liner side) Material: 1.4404 (body side) 1.4301 (liner side)
- Safety relief valve calibration pressure: 2.9 bar
Semi-automatic machines available in two models
Ideal for small productions, start-ups or laboratory studies in a sterile/non-sterile environment
Manual loading of single-dose containers
Suitable for pharmaceutical, cosmetic and other products, liquids, creams and gels
Maximum flexibility and versatility, seals containers of different materials and capacities
Wide range of accessories and optional features
Compact, suitable for small areas, ideal for use in existing or new production sites, for laboratories, for clinical/stability tests
Easy use and maintenance
This mixer is specially designed for delicate mixing where there is danger of breakage and not to create dust. The mixing time varies between 5 and 20 minutes depending on the type of mixing. It consists of two openings: the loading and washing mouth, and the discharge mouth which has an automatic valve with a pneumatic actuator. The ports have an airtight closure to prevent environmental contamination during the mixing phase. Inside it includes a cone mounted in the rotation axis on both sides. With this system, dead space formation is avoided by facilitating gravity discharge
The biconical type mixer realizes homogeneous mixing of solids. The mixing process is a common operation in production intended for the food, cosmetic, pharmaceutical, chemical, detergent, fertilizer and plastics industries. Some examples are pharmaceutical granulates, flour semolina, seeds, starch, coffee beans, milk powder, infant formula, dehydrated cream and soup processing preparations, foliar waxes, granulated detergents, flaked soaps, artificial fertilizers, powdered or shredded plastics, glass fibers, etc.
The mixing body consists of two cones joined at their base through a cylindrical section. The axis of rotation is perpendicular to the axis of the cones and passes through the same cylindrical section. The two supports located in the laterals contain the motor and secure the mixing body. The solid is introduced through the inlet. In this type of mixer, axial level mixing is produced, due to the slippage of the powder in the distinct sections. It is a precise mixer on which the speed of rotation influences. Discharge of the mixture is accomplished by means of a butterfly valve with a manual or automatic hermetic seal. The equipment is equipped with an electrically protected perimeter guard to prevent operator access when in operation. For safety, if the perimeter is accessed, the mixer will cease operation.
All product-contact parts of this equipment are made of AISI 316 (EN 14404) steel, while the bases and other elements are made of AISI 304 (EN 14301) steel. Thanks to the hygienic design and the absence of corners, cleaning is easy both manually and by means of the automatic CIP system. The equipment is also equipped with perimeter protection with a door complying with CE safety standards.
The automatic stop positions are: loading, unloading and sampling. Before stopping in any of the above three positions, the equipment runs a cycle that slows down the mixer so that it can stop and brake with precision. This equipment is designed, unlike the “V” type. , for mixing granulated products or powders with different densities, with a loading capacity of about 65% of the total capacity of the plant, unlike the “V” type that only can be loaded to 50%, for mixing powders or granulates with the same or similar densities.
530 SERIES
Coster best-seller semi-automatic machines for technical and cosmetic applications, suitable for filling of products, valves’ crimping, filling of propellants
• Top production speed 10/15 CPM
• Possibility of two head positions
• Atex compliant
• Fully pneumatic, Atex compliant
• Available electronic upon request
Usable shelf area: 8.9 m2 (8 usable shelves of 914 mm x 1219 mm)
Shelf spacing 105 mm
These 2 elements should allow you to calculate the number of vials and the type of vials (>100
mm).
Condenser capacity : 150 kg of ice
Shelf cooling: 1.75°c/min with maximum attained at -53°c
Heating shelves: 2°c/min, max T°c shelves 65°c
ATM pressure at 0.1 mbar in 30 minutes
Maximum vacuum reached: 0.003 mbar
Pressure increase rate: 0.005 mb x l/s
Automatic feeder for tablets Cartoner for blister Marchesini Model MA 305 from 2002.
Continuous movement machine.
Automatic blister feeding GUK leaflet folder.
Bar code reader.
Booklet feeder System coding for the cartons.
Range of work min. 25 x 15 x 65 mm Max. 100 x 85 x 150 mm.
Speed up to 240 cartons per minute.
Check weigher Garvens S2 from 2000.
Filling and capping line Groninger for injectables composed of:
1) Groninger DFVN 2005VI filling machine
> Provides versatility in format and batch size
> Semi-automatic debagging machine MWU010
> Fully automatic (de)lidding MWF100
> Fully automatic nest filling & stoppering machine
> DFVN 2005VI – 5-headed aseptic filling line (max.200 pieces/min) combined with nested technology
> 100% IPC
> Operating under Franz Ziel isolator
> Gassing before stoppering
2) Groninger KVK208B capping machine
> Max 300 pieces per minute
> Fully automatic closing system
> Operating under RABS
> Single lane discharge tray loading system for vials
> All equipment uses Groninger Process Data System
> Versatile formats through ready-to-use components via single operational line
> Formulation in Grade A (under isolator) or C classification
Speed up to 12000 pc/h
> Supports products of various levels of viscosity (up to 1,500 CPS) with regular and vacuum technology and rotative or peristaltic pumps
> Possibility to process under nitrogen atmosphere
> Received GMP certification
Equipment work ranges
Diameter 6.9 – 31.5 mm
Height 35.0 – 155.0 mm
Volume 0.2 – 50.0 ml
Available formats at Metis
Vials 2R and 6R (0.5 – 10.0ml)
1.0 – 3.0 ml (standard syringe)
PFS 2.25 ml (PRTC syringe)
Cartridges 3.0 ml
> Presentation versatility is determined by the equipment’s work ranges
> Majority of clients use standard presentations for vials, prefilled syringes and cartridges
3 Closed and open ampoules filler Cioni A6FC from 1976/1978/1979
Automatic filling machine for closed and / or open ampoules with automatic loading and
unloading. The machine automatically loads the ampoules 6 by 6, turns them upside
down, opens them, turns them over and fills them with 6 syringes and seals them,
unloading them on a tray.
All these operations are carried out with a single operator. The machine also works for open blisters.
Formats included for 1-2 ml
The equipment comes with its laminar flow
Technical data:
Hourly production: 12,000 units.
Maximum diameter of the vial: 19 +/- 19.5 mm
Dosage: 1 +/- 10 ml.
Feed to load: width max. 310 +/- 315mm - width min. 160mm - length max. 500mm
Discharge: width max. 365mm - width min. of the individual basket 160mm - length max.
500mm
Machine measurements: width 2300 x length 1940 x height 1600 mm
Net Weight: 460KG
Gross Weight: 780KG
Installed potency:
220-380V 50Hz Absorption A. 220V A. 6.5 - A. 380V A. 4.2
Pressures:
G.P.L. min. Kg / cmq. 0.6 - max. Kg / cmq. 2 +/- 3
Oxygen min. kg / cmq. 1 - max. kg / cmq. 3
Nitrogen min. kg / cmq. 0.4 - max. kg / cnq. 1.2 +/- 1.3
Körber / Mediseal Blister line composed of BLISTER MACHINE CP400 and CARTONER P1600
1) The CP 400 from Körber today represents a perfectly mature product for the pharmaceutical industry. All areas of the high-performance single-lane blister machine are clearly visible, easily accessible, and quick to clean. Its well-thought-out GMP concept provides maximum production reliability, while the central format data management via the operating terminal enables fast format changes. In combination with the P1600 cartoner, this machine can be upgraded into a compact line. Your benefits Economical Low servicing and maintenance costs Flexible Fast format changes in less than 45 minutes via central format data management system Precise Exact positioning of the blisters before sealing, punching and perforating, thanks to servo-driven take-offs
Maximum film width 160 mm
Technical specifications
Maximum reel diameter 500mm or special version
Maximum reel core diameter 76 or 152 mm (depending on version)
Maximum feed length forming station 220 mm
Maximum feed length sealing station (for flat sealing only) 220 mm or special version 260 mm
Maximum feed length station 110 mm or 80 mm in connection with a Pacliner
Maximum depth of blister 12 mm
Performance max. 400 blisters per minute (depending on the product)
2) The P1600 cartoner has been specially designed for packaging small and
medium-sized lot sizes. The indexed method of operation means that the cartoners not only
occupy a minimum footprint but also require few format parts, which can also be swapped out quickly and simply. Carton height adjustment is performed automatically via an actuator.
Whether it is a matter of the transfer systems, carton separation, leaflet feed, product insertion or closing systems – the P1600 rely on the same proven assemblies and principles.
The P1600 is also able to handle very large cartons, with an output of 80 to 150 units per minute.
The integrated servomotor drive concept ensures a clear layout of all function units which is easy to monitor visually. Components which are moved mechanically have been
largely eliminated by applying servo technology. Servicing and maintenance of the P1600 is simple and costs considerably less than purely mechanical systems. A modem, fitted as standard, enables any machine malfunctions to be identified and rectified quickly by remote
access.
The P1600 is designed as standard for installation of the latest generation of GUK 2000 folders. The folders are driven via their own servo shaft, so there is no need for adjustment via a mechanical clutch.
GMP-compliant construction and a minimum number of format parts make full format changes possible in less than 30 minutes. Carton height adjustment on the P1600
takes place automatically by motorized raising or lowering of the upper runner unit. Simultaneous guidance for the carton via upper and lower runners ensures stable transport during packaging, even for height-to-width ratios < 1
Technical details :
Pitch 120 mm
Carton lenght 65 – 150 mm
Carton width 35 – 90 mm
Carton height 15 – 95 mm
Output , cartons per minute 10 – 150
Noise emission Less than 70 dB
blister machine IMA C80R for alu – alu and alu – pvc
the module of c80r stand-alone blister machine allows the maximum flexibility in connection with cartoners, wallet machines and flow pack machines, satisfyng any kind of line layout needs.
FORMING REEL HOLDER
Standard and semi-automatic reel holder, which allows forming material splicing
without production stop, are both available.Reel diameter up to 800 mm.
With the semi-automatic reel holder, when the reel is near to the end, the automatic
lifter starts the second reel holder without machine stop, allowing the operator to
install the new reel
HEATING
Four heating sections in order to heat the film gradually and uniformly can be set
independently through the HMI. The heating area is completely accessible for
maintenance and does not have any cables or tubes in view.
When the machine stops, the plates open and there is no contact with the film in order to
prevent film damage
FORMING
Possibility to handle all types of forming materials - ALU, PP, PVC, PVC/PVDC, Triplex,
PVC/Aclar®, PET, COC just to mention few - by using different forming process i.e. air
pressure, heated plugs combined with air pressure or plugs only in order to obtain a
perfect formed film
FEEDING
Feeding area has been designed for very fast cleaning operations and to easily allow
the installation of different feeding systems such as chute feeders, roller feeders, brush
box feeders and customized feeders.
SEALING
IMA Safe’s continuous roller sealing grants the best performance and sealing quality
thanks to the constant check of temperature, pressure and speed.
The sealing pressure check is made by a selfregulating load cell placed directly into the
sealing roller mechanism, which is very precise.
VERY QUICK AND EASY CHANGEOVER:
ALL TOOLING, SIZE PARTS, GUIDES, ETC, ARE REMOVED BY SIMPLY PULLING OR
SLIDING THEM INTO THE APPROPRIATE SLOT, NO TOOLS ARE REQUIRED.
BLISTER DIMENSIONS
Width 30-90 mm
Length 60 – 150 mm
Depth 3-12 mm
PRODUCTION OUTPUT UP TO 400 – 600 blister/min
Include pin hole detector HPF
Scanware vision system model : E – 323/B132
Wallet and cartoning machine Schubert TLM-F2
with accessories
Stand-alone system
with additional tools and large spare parts package
Two integrated laser labelling systems (Domino company)
Inspection of variable data (Systech company)
Filling and stopper inserting machine for syringes in nests Groninger, model DFVN1000, dated 2009, that has never been used after SAT. The machine can be connected for a short test in case of inspection.
It is for small scale or lab, with max output 4.800/hr
Manual and IQ/OQ are available.
It has 2 rotary piston pumps with 2 filling needles. Gassing during filling and during stoppering
The equipment is designed to operate 1,0 ml syringes
Syringe diameter : 8,15 mm with corresponding stoppers
Syringe 1 ml BD long
Nest type 160 syringes per nest
Output: 4800 syringes per hour
Technical details:
Electrical connection: 220/380 V, 50 Hz, 3 Ph+N+PE
Power consumption: Approx. 7 KVA
PLC: Siemens S7
Operator panel: Siemens MP370
Filling station: 2 rotary piston pumps, hoses and filling needles
Dosing range: 0,2 ml – 1,5 ml
Working range syringes: Diameter from 6,85 mm to 29,85 mm
Stopper inserting station: Vibratory sorting bowl with 2 feeding tracks and inserting tools
Working height machine: 1115 mm ± 15 mm
Finishing: Stainless steel, anodized Aluminium and suitable Plastics
Varnish: RAL 9007
2.1 Main process steps
The Functional Specification describes the tasks and functionality of the following main process steps of the filling and stopper inserting machine for syringes in nests:
- A tub with nest and empty syringes is placed by an operator onto the tub handling station. The operator peels off the both top sheets of the syringe tub completely.
- The operator moves the nest with empty syringes out of the tub onto the nest handling station and pushes it in a defined position at the inside of the machine. Now the operator can start the filling and stopper inserting process via a respective button which is located at the operator panel.
- The nest is moved lengthwise and sidewise into exact position for filling and stopper inserting process by means of a centering frame.
- At the filling station (filling at two positions), consisting of two rotary piston pumps with filling needles and hoses, the syringes are filled with product.
- Gassing during filling.
- A stopper inserting station (stopper inserting at two positions) consisting of vibratory sorting bowl, two feeding tracks and inserting tools is used to feed the stoppers and to insert them into the syringes.
- Check stations stopper presence and stopper orientation at feeding track 1.
- Check stations stopper presence and stopper orientation at feeding track 2.
- Gassing during stopper inserting.
- Faulty operated nests are displayed on the operator panel.
- After filling and stopper inserting the nest will be transferred back into defined position.
- The operator pulls the nest with filled and closed syringes out of the machine onto the nest handling station.
- Now the operator moves the operated nest from the nest handling station onto the tub handling station and places it into the inside of the respective tub.
- Integration of a Batch protocol system.
CP-Citopac FKS-10 CP overhauled 2023
Suppository, filling, cooling, and sealing machine for preformed plastic packages consisting of:
- Filling machine SFD10CP with two filling points (dosage per filling point from 0.5 to 3.5ml)
- KTE-10 CP cooling tunnel with a cooling path of approx. 25m
- BST-10 CP sealing machine for sealing openings on pre-formed plastic packages
Adjustable production capacity up to approx. 10,500 suppositories/hour
The CP-CITOPAC FKS-10CP is designed for uninterrupted use with maximum operational demands. It is compact and carefully constructed using a combination of materials such as aluminium, stainless steel, viton and Teflon.
Atomizer / Spray dryer GEA Niro FX1
Technical data:
motor:
type High-frequency motor, 2-poles, IP55, Eexd IIC T4 with three thermostats (connected in series)
Rotation: Anti-clockwise when viewed from above
Voltage: Y 19-380V
Frequency: 25-500 Hz
Current: 3.58 A
Power: 0.075 - 1.5 kW
RPM:1,500 - 30,000
Atomiser:
Min RPM: 10,000 (atomiser speed at 167 Hz)
Max. RPM: 30,000 (atomiser speed at 500 Hz)
Cooling air:
Air flow rate: 210 kg/h, at max. temperature 35°C
Min. Pstat.: 65 mm WG at atomiser inlet.
Noise level:
The sound pressure level (SPL) in the vicinity of the atomiser depends on:
- turbine speed
- load of the atomiser
- type and size of the motor
- the environment surrounding the mistblower.
Under normal operating conditions, the SPL at a distance of 1 metre from the FX1 mistblower is measured at 84 dB(A). This value, however, should be regarded as indicative. A variation up to a maximum of 5 dB(A) or more may be found under the above circumstances.
If the sprayer is fitted with a silencer, the sound pressure level (SPL) is measured at 70 dB(A) at a distance of 1 metre.
Weight
Sprayer weight (including turbine): 19.5 kg
Marchesini MA302 medium-speed continuous motion horizontal cartoning machine, particularly suitable for packing deep thermoformed trays for ampoules and syringes.
Main features:
- Versatility and efficiency in a small footprint
- Balcony design for easy access
- Oil-bath main drive unit
- Synchronised servo motors
- Motorised carton length adjustment
- Carton opening via rotating drum
- Easy and intuitive format change
- Product-carton-departon cross-checking
- Chain conveyor
- Wolke coding system
- GUK folder folder
- Rontech booklet feeder
- Sea vision control system
- Hot melt Nordson
OUTPUT
Speed: Up to 210 cartons/min
PRODUCT RANGE
Carton width: MA300: 25 - 100 mm
Carton height: MA300: 15 - 85 mm
Carton length: MA300: 65 mm - 150 mm
Via XXV Aprile, 8
21054 Fagnano Olona (VA)
Italia
Tel. +39 0331 1693557
email: inti@intisrl.it
