Automatic intermittent and continuous motion horizontal and vertical cartoners
For medium-high production.
Alternating movement, equipped with numerous opional including insertion leaflet.
Up to 5.000 units/hour Carton dimensions - 20/100 x 15/70 x 60/220 Power : 2 kw Consumption : air 50 l / min
COMPLETE SYRINGE FILLING LINE OPTIMA GROUPS • 2007
1. Debugger machine Bausch&stroebel model LFO 9060 from 2012
2. Belt under laminar flow Optima Inova
3. Robot for Tyvek removal Optima Inova model TRR •
4. Filling machine Optima Inova model H6-10
5. denester machine Optima Inova model SH260
6. inspection machine Brevetti Cea model k15\600 •
7. Renester machine Optima Inova model SN260 •
Syringes diameter 10.85
speed 400 pz\min
Automatic Vial or Ampoule Leak Detection Machine Bosch KLD1042 from 2008
Diameter of ampoules min./maxi.: 10 - 32 mm
Speed : 24,000 ampoules/ hour up to Ø 13 mm (ampoule of 3ml and 18,000 ampoules/ hour up to Ø 18 mm (ampoule of 5ml or vial of 4R)
Bundler Skinetta 300
Film width single lane 30-450 mm / tandem 2 lanes 30-290 mm each.
Material: Polyethylene (polypropylene conditionally)
Properties high elasticity, good sliding properties, low tension drop over time
Thickness 25-60my (also possible above), depending on packaged goods, pack type and film width Thickness tolerance +/- 10%.
Width: depending on pack size, pack type
Roll diameter: standard outside approx. 300 mm (up to 600 mm possible)
FSV 1111 - Colanar Innovative Solutions is designed for filling syringes in the pharmaceutical field.
- Insertion of the syringe into the nest holder by the operator
- Process start via HMI Touch Screen
- Automatic positioning of the syringe
- Washing the syringe with nitrogen before filling
- Filling /inserting rubber stopper with vacuum capping
120 Volts
Technical specifications
◦ Output: up to 25 / min
◦ Filling range: 50μl to 20 ml
◦ Range:
◦ 0,5 - 20 ml nested syringes
◦ 2 - 20 ml nested vials
◦ 1,5 - 3 ml nested cartridges
The machine is set up for syringe of 160 unit trays of 1 ml with 2 different filling system
Technical Data
Output: Up to 25 syringes/ min.
Filling Range: 50 μl to 20 ml
Dimensions: Approx. 1020 mm x 1200 mm x 1940 mm (40” x 47” x 76”)
Working height: 930 mm (37”)
Weight: Approx. 500 kg (1100 lbs)
Power: 120V, 60 Hz, 20A
Controls: Panasonic PLC, Servo Drives, and HMI
Finish: All surfaces Stainless Steel and Plastics
Utilities: Varian Vacuum Pumps (included)
Compressed Air: 4 bar (60 psi), 85 l/min (3 cfm)
1)Ampoule filler under isolator
Producer : Bosch
Model : ALK 4080
Year of manufacture : 1997
Production : 400 ampoules per minute working range
Diameter : From 9 up to 18 mm
Height : From 60 up to 110 mm
Formats incluided : 1 - 2 -5 - 10 ml ( to be confirmed )
The machine comes with ISOLATOR and DEDICATE AHU
2) Depyrogenation owen for ampoules Bosch Producer : Bosch Model : HQL 3420
Year : 1997
Production : 24.000 ampoules of 1 ml per hour
HQL facilities are ideal for vial sterilization.
This model is exceptional due to the lack of passage in the tunnel, which is the result of the laminar hot air flow process with its high degree of efficiency. Sterilization tunnels are used in pharmaceutical industry filling lines to sterilize glass containers before aseptically filling them.
These tunnels use forced air at temperatures up to 350 ° C.
Bosch HQL drying and sterilization tunnels operate with unidirectional flow, with process curves of temperature progression and significantly reduced sterilization times.
They guarantee the consistent precision necessary for validation, qualification, and reliable production capacity.
Through a filter, the make-up air is introduced into the tunnel.
Inside the tunnel, the air, drawn in by the fans, feeds the supply and cooling section through the pre-filters and the air particle filters in the separate areas of the tunnel.
Using the laminar flow principle, the air flow is directed vertically in the containers.
Below the conveyor, the air is directed back through a recirculation duct to the fan.
The fans need fresh air for the heating section: laminar flow unit.
The heating elements in the recirculation duct serve to heat the recirculation air to the preset temperature.
Below the particulate air filters are heating elements that are output to a recording and temperature control device.
The cooling section works with laminar flow. A fan in the cooling section draws the hot air under the conveyor belt.
The volume of exhaust air is adjusted automatically.
The tunnel is equipped with an automatic overpressure control in the cooling section.
Modular system for tunnel assembly suitable for the required power range with optimal energy consumption. Construction according to GMP. Compatible container transport systems for stable and non-stable containers. Safe conveyor belts on the floor and side levels operated simultaneously. Excellent accessibility and ease of operation.
Ampoule washing machine with different washing cicles
(water WFI - sterile air )
Producer : Bosch
Model :RRU 3082
Year of manufacturing :1997
Production : 400 ampoules per minute
Working range : Diameter : 9 - 18 mm
Height : 60 - 110 mm
Formats included : 1 -2 - 5 - 10 ml ( to be verified )
The Bosch RRU series of washers and dryers perform ultrasonic cleaning for fast and accurate removal of particulate matter.
Its swivel design allows for a small footprint and ease of operation with fast and accurate removal of particulate matter and reliable feeding of small containers. RRU Bosch rotary heads will give you excellent results with gentle vial handling. They can be configured for a wide range of formats.
Rotary washer ideal for cleaning vial bottles.
Exceptional for its optimal accessibility, for example, and it is very easy to use. Processing ranges and capacities depend on individual containers, line integration, etc.
Construction according to GMP; reduced size; safe transport of containers; high level of ultrasonic cleaning; stations for internal and external container washing; with the pumping station; fast format change.
COLOR RING PRINTER BOSCH DRN 3010
This high-speed machine is design to mark ampoules with single or multiple ring codes.
It is useful for identifying trial batches or for adding colour codes to standard batches of Ampoules for identification purposes or to avoid intermixing of batches.
• Included format sets 1 ml - 2 ml - 5 ml- 10 ml To be verified
Complete line for ampoule Bosch 24.000 per hour with Isolator from 2009 Composed of :
1) Ampoule filler under isolator
2) Depyrogenation owen for ampoules Bosch
3) Ampoule washing machine with different washing cicles
4)Air Handling Unit
1-Ampoule filler under isolator • Producer : Bosch • Model : ALF 4080 Year of manufacture : 2009 • Production : 400 ampoules per minute working range • Diameter : From 9 up to 30 mm • Height : From 60 up to 160 mm • Formats incluided :1 - 2ml • The machine comes with ISOLATOR and DEDICATE AHU AND CIP/ SIP IPC ( weigh control ampoules ) • The ALF series of machines meets all the prerequisites for modern ampoule production. The convincing line concept. • Wide experience, state-of-the-art know- how, highly developed engineering and Bosch quality – new dimensions for dependability, economy and flexibility with easy operator control. • The ALF series was configured in accordance with pathfinding, pharmaceutically compliant findings to provide a modern, ergonomic design that supplies the customer with maximum benefits. Decisive in this design is a basic ma-chine that can be equipped and retrofitted with various equipment units. These include: • In-process control system • Infeed and outfeed starwheel • Isolator version Work and production considerations: • Easy operator control due to the slim, tidy, clearly laid-out construction Easy cleaning. • All machine functions can be overseen, controlled and operated from one position at the front. • Clean Room compliance. • Drive and production segments are clearly separated: worktop right through. • The ampoules are transferred directly from the sterilizing tunnel to the ALF infeed belt. • Via a scroll conveyor and transfer wheel the ampoules reach the conveying system by means of which they are con-ducted through the work stations: gasflushing, filling, sealing. • Each filling point controls individually contactless scanning of the ampoule necks – "no ampoule – no filling". The ampoule necks are precentred by the draw-off grippers, the ampoule tips are then grasped and fed into a collection container. • During the sealing procedure post-gasflushing can take place. The filled and sealed ampoules are pushed virtually load-free into the outfeed magazine. Rotary slide pumps: • Bosch provides precision filling for parente- ralia with its proven rotary slide pump. Product- conserving and drip-free filling to the highest degree of filling precision are ensured for a wide range of different properties. • Bosch seal-free rotary slide pumps have easy vertical cleaning paths. Technical in the lead: • 3-part: rotary slide valve, pump cylinder,Pump piston. • Seal free. • Easy, vertical cleaning paths. ❒ • CIP/SIP capability. 2) Depyrogenation owen for ampoules Bosch Producer : Bosch Model : HQL 2440S Year : 2009 Production : 24.000 ampoules of 1 ml per hour HQL facilities are ideal for vial sterilization. This model is exceptional due to the lack of passage in the tunnel, which is the result of the laminar hot air flow process with its high degree of efficiency. Sterilization tunnels are used in pharmaceutical industry filling lines to sterilize glass containers before aseptically filling them. These tunnels use forced air at temperatures up to 350 °C. Bosch HQL drying and sterilization tunnels operate with unidirectional flow, with process curves of temperature progression and significantly reduced sterilization times. They guarantee the consistent precision necessary for validation, qualification, and reliable production capacity. Through a filter, the make-up air is introduced into the tunnel. Inside the tunnel, the air, drawn in by the fans, feeds the supply and cooling section through the pre-filters and the air particle filters in the separate areas of the tunnel. Using the laminar flow principle, the air flow is directed vertically in the containers. Below the conveyor, the air is directed back through a recirculation duct to the fan. The fans need fresh air for the heating section: laminar flow unit. The heating elements in the recirculation duct serve to heat the recirculation air to the preset temperature. Below the particulate air filters are heating elements that are output to a recording and temperature control device. The cooling section works with laminar flow. A fan in the cooling section draws the hot air under the conveyor belt. The volume of exhaust air is adjusted automatically. The tunnel is equipped with an automatic overpressure control in the cooling section. Modular system for tunnel assembly suitable for the required power range with optimal energy consumption. Construction according to GMP. Compatible container transport systems for stable and non-stable containers. Safe conveyor belts on the floor and side levels operated simultaneously. Excellent accessibility and ease of operation. 3) Ampoule washing machine with different washing cicles (water WFI - sterile air ) Producer : Bosch Model :RRU 3084 Year of manufacturing :2009 Production : 400 ampoules per minute Working range : Diameter : 9 - 30 mm Height : 60 - 145 mm Formats included : 1 -2 ml The Bosch RRU series of washers and dryers perform ultrasonic cleaning for fast and accurate removal of particulate matter. Its swivel design allows for a small footprint and ease of operation with fast and accurate removal of particulate matter and reliable feeding of small containers. RRU Bosch rotary heads will give you excellent results with gentle vial handling. They can be configured for a wide range of formats. Rotary washer ideal for cleaning vial bottles. Exceptional for its optimal accessibility, for example, and it is very easy to use. Processing ranges and capacities depend on individual containers, line integration, etc. Construction according to GMP; reduced size; safe transport of containers; high level of ultrasonic cleaning; stations for internal and external container washing; with the pumping station; fast format change.
Complete line for ampoule Bosch 24.000 per hour with Isolator from 2009 Composed of :
1) Ampoule filler under isolator
2) Depyrogenation owen for ampoules Bosch
3) Ampoule washing machine with different washing cicles
4)Air Handling Unit
1-Ampoule filler under isolator • Producer : Bosch • Model : ALF 4080 Year of manufacture : 2009 • Production : 400 ampoules per minute working range • Diameter : From 9 up to 30 mm • Height : From 60 up to 160 mm • Formats incluided :1 - 2ml • The machine comes with ISOLATOR and DEDICATE AHU AND CIP/ SIP IPC ( weigh control ampoules ) • The ALF series of machines meets all the prerequisites for modern ampoule production. The convincing line concept. • Wide experience, state-of-the-art know- how, highly developed engineering and Bosch quality – new dimensions for dependability, economy and flexibility with easy operator control. • The ALF series was configured in accordance with pathfinding, pharmaceutically compliant findings to provide a modern, ergonomic design that supplies the customer with maximum benefits. Decisive in this design is a basic ma-chine that can be equipped and retrofitted with various equipment units. These include: • In-process control system • Infeed and outfeed starwheel • Isolator version Work and production considerations: • Easy operator control due to the slim, tidy, clearly laid-out construction Easy cleaning. • All machine functions can be overseen, controlled and operated from one position at the front. • Clean Room compliance. • Drive and production segments are clearly separated: worktop right through. • The ampoules are transferred directly from the sterilizing tunnel to the ALF infeed belt. • Via a scroll conveyor and transfer wheel the ampoules reach the conveying system by means of which they are con-ducted through the work stations: gasflushing, filling, sealing. • Each filling point controls individually contactless scanning of the ampoule necks – "no ampoule – no filling". The ampoule necks are precentred by the draw-off grippers, the ampoule tips are then grasped and fed into a collection container. • During the sealing procedure post-gasflushing can take place. The filled and sealed ampoules are pushed virtually load-free into the outfeed magazine. Rotary slide pumps: • Bosch provides precision filling for parente- ralia with its proven rotary slide pump. Product- conserving and drip-free filling to the highest degree of filling precision are ensured for a wide range of different properties. • Bosch seal-free rotary slide pumps have easy vertical cleaning paths. Technical in the lead: • 3-part: rotary slide valve, pump cylinder,Pump piston. • Seal free. • Easy, vertical cleaning paths. ❒ • CIP/SIP capability. 2) Depyrogenation owen for ampoules Bosch Producer : Bosch Model : HQL 2440S Year : 2009 Production : 24.000 ampoules of 1 ml per hour HQL facilities are ideal for vial sterilization. This model is exceptional due to the lack of passage in the tunnel, which is the result of the laminar hot air flow process with its high degree of efficiency. Sterilization tunnels are used in pharmaceutical industry filling lines to sterilize glass containers before aseptically filling them. These tunnels use forced air at temperatures up to 350 °C. Bosch HQL drying and sterilization tunnels operate with unidirectional flow, with process curves of temperature progression and significantly reduced sterilization times. They guarantee the consistent precision necessary for validation, qualification, and reliable production capacity. Through a filter, the make-up air is introduced into the tunnel. Inside the tunnel, the air, drawn in by the fans, feeds the supply and cooling section through the pre-filters and the air particle filters in the separate areas of the tunnel. Using the laminar flow principle, the air flow is directed vertically in the containers. Below the conveyor, the air is directed back through a recirculation duct to the fan. The fans need fresh air for the heating section: laminar flow unit. The heating elements in the recirculation duct serve to heat the recirculation air to the preset temperature. Below the particulate air filters are heating elements that are output to a recording and temperature control device. The cooling section works with laminar flow. A fan in the cooling section draws the hot air under the conveyor belt. The volume of exhaust air is adjusted automatically. The tunnel is equipped with an automatic overpressure control in the cooling section. Modular system for tunnel assembly suitable for the required power range with optimal energy consumption. Construction according to GMP. Compatible container transport systems for stable and non-stable containers. Safe conveyor belts on the floor and side levels operated simultaneously. Excellent accessibility and ease of operation. 3) Ampoule washing machine with different washing cicles (water WFI - sterile air ) Producer : Bosch Model :RRU 3084 Year of manufacturing :2009 Production : 400 ampoules per minute Working range : Diameter : 9 - 30 mm Height : 60 - 145 mm Formats included : 1 -2 ml The Bosch RRU series of washers and dryers perform ultrasonic cleaning for fast and accurate removal of particulate matter. Its swivel design allows for a small footprint and ease of operation with fast and accurate removal of particulate matter and reliable feeding of small containers. RRU Bosch rotary heads will give you excellent results with gentle vial handling. They can be configured for a wide range of formats. Rotary washer ideal for cleaning vial bottles. Exceptional for its optimal accessibility, for example, and it is very easy to use. Processing ranges and capacities depend on individual containers, line integration, etc. Construction according to GMP; reduced size; safe transport of containers; high level of ultrasonic cleaning; stations for internal and external container washing; with the pumping station; fast format change.
stainless steel dissolving tank for storing and transferring liquids (approx. 550 litres).
SECTOR OF USE:
Pharmaceutical, chemical, cosmetic, food, dietary, medical devices.
PECULIARITY:
The equipment is designed to high and proven engineering standards, the machine provides the user with a high degree of quality and reliability designed to achieve the best possible results in terms of product purity. The tank by its natural propensity lends itself to pharmaceutical and chemical processes. The dissolver is a dynamic tank for dissolving powdered products in a liquid solution. It is constructed in a cylindrical shape and made of stainless steel, with a sloping bottom.
HDI series leak test control machine NIKKA DENSOK DMI Verification of losses in plastic ampoules and monodose BFS Features of the HDI machine 100% inspection by BFS production non-destructive testing test 1-4 inspection stations Speed up to 110 card/min Easy change of format measures Compliant with 21 CFR Part 11 automatic feeding system Single-dose strip automatically fed on the conveyor belt for inspection in the correct time sequence by means of servo motor
General information Inspection stations: 1 – 4 stations
Maximum measurements of the strip: L110mm/W150mm
Capacity: 6600/hour.
Energy consumption: 1KVA
Electric power supply: 200 ~ 480VAC, 50/60Hz, 3 phases
Environment: Ambient temperature: 10o ~ 35oC
Ambient humidity: 20 ~ 80%
Product Conductivity: 1.5μS (400 KΩ sopra)
Preparation vessel for sterile with double jacket and magnetic mixer
Manufacturer: Civinox
Volume of the useful container: 290L
Tank maximum admissible internal pressure: 3/ -1 bar
Jacket maximim admissible pressure 3 bar
Reactor project maximum temperature: +143 °C
Jacket project maximum temperature +143 °C
Jacket capacity Lt
Material in contact : AISI 316 L
magnetic stirring system
Preparation vessel for sterile with double jacket and magnetic mixer
Manufacturer: Civinox
Volume of the useful container: 505L
Tank maximum admissible internal pressure: 3 bar
Jacket maximim admissible pressure 3 bar
Reactor project maximum temperature: +143 °C
Jacket project maximum temperature +143 °C
Jacket capacity 55 Lt
Material in contact : AISI 316 L
magnetic stirring system
Preparation vessel for sterile with double jacket and magnetic mixer
Manufacturer: Civinox
Volume of the useful container: 94L
Tank maximum admissible internal pressure: -1/ 3 baR
Jacket maximim admissible pressure 3 bar
Reactor project maximum temperature: +143 °C
Jacket project maximum temperature +143 °C
Jacket capacity 19 Lt
Material in contact : AISI 316 L
magnetic stirring system
KLOCKNER P4/200 CARTONING MACHINE WITH AUTOMATIC BLISTER FEEDER IN LINE WITH BLISTER MACHINE
Manufacture : Klockner Model : P4/200 Carton range : width 30 x 115 mm - height 12 x 90 mm lenght 60 x 150 mm Mechanical speed : 200 cartons per minute Dimension of the machine : 5180 x 1500 x 1640 mm Weight : 3.300 Kg. Year of manufacturing 1996
montaliquid dissolutor TECNINOX 200 lt. Wheel-mounted Model ISPESL 1445/85/PR
Via XXV Aprile, 8
21054 Fagnano Olona (VA)
Italia
Tel. +39 0331 1693557
email: inti@intisrl.it