HQL installations are ideal for the sterilisation of vials.
This model is exceptional because of the low throughput in the tunnel, which is the result of the laminar hot air flow process with its high degree of efficiency.
Sterilisation tunnels are used on filling lines in the pharmaceutical industry to sterilise glass containers prior to aseptic filling.
These tunnels use forced air at temperatures of up to 350°C. Bosch HQL drying and sterilisation tunnels operate with unidirectional flow, with process curves of temperature progression and significantly reduced sterilisation times.
They guarantee the constant precision required for validation, qualification and reliable production capability. Through a filter, make-up air is introduced into the tunnel. Inside the tunnel, the air, drawn in by fans, feeds the supply and cooling section through pre-filters and particulate air filters in separate areas of the tunnel. Using the laminar flow principle, the air flow is directed vertically into the containers. Underneath the conveyor belt, the air is directed back through a recirculation duct to the fan. The fans need fresh air for the heating section: laminar flow unit. The heating elements in the recirculation duct serve to heat the recirculation air to the preset temperature. Below the particulate air filters there are heating elements with an outlet to a temperature control and recording device. The cooling section operates with laminar flow. A fan in the cooling section exhausts the hot air under the conveyor belt. The exhaust air volume is automatically adjusted.
The tunnel is equipped with an automatic overpressure control in the cooling section. Modular system for tunnel assembly suitable for the required power range with optimum energy consumption. GMP-compliant construction. Compatible container transport systems for stable and unstable containers. Safe conveyor belts on floor and side levels operated simultaneously. Excellent accessibility and ease of operation.
Technical data
Length 2865 mm
Width mm 2200
Height 2630 mm
Weight Kg 3500
Number of punch stations 55
Output tablets 594,000/h
Max. tablet diameter 13 mm
Max. filling depth 18 mm
Max. tablet thickness 8,5 mm
Max. compression force 100 kN
Max. initial compression force 20 kN
Dieplate speed 15-90 rpm .
Dimensions of the machine : 1490 x 1230 x 2100
Weight approx. 3750 Kg
Bottle filling machine with spray (nasal spray)
Current bottle 10 ml, 400V / 50Hz
Production 12. 000 bottles / h
6 filling stations, with self-priming rotary piston pumps made of stainless steel
Dosing accuracy +/- 0.5%
Insertion of spray pump, one vibrating loader
C-BOSCH capping machine for pressure cap
Type VRK 4010
Max. production 12,000 bottles / h
Format for vials Diam 21.5 x H 50 and 60 mm (10-14 ml)
Aluminium cap diam 20 mm.
8 filling pumps
Ejection of non-conforming products under laminar flow, continuously controlled by a hot wire anemometer and a particle counter connected to the EUROTHERM environmental monitoring system
Turntable
Dimensions (in m): Excluding hoppers and electrical cabinet: L 4.40 x W 1.60 x H 1.90 m (1500 Kg)
Max speed : Up to 400 bottles/minute
Nominal output : 250 / min. C - NERI TM2 loading machine from 2011
Dimensions (in m): Excluding infeed conveyor: L 2.38 x W 1.25 x H 1.42 m (excluding console)
Set of sizes PFS 0.5ml, 1ml long, 5ml
Workflow: The tubs are already fed on the infeed roller conveyor without overloading. There are no devices on the machine to open the overbag or to dispose of it. The syringe at the end of the roller conveyor is lifted manually onto the automatic through-feed conveyor. Then the Tyvek closure is removed manually. The tank is transported further; the nest is lifted and placed in the x-y table. The syringes are filled and sealed with caps. During the filling and/or sealing process, the formation of N2 gas is possible. The filled tanks are transferred from the automatic conveyor belt to the discharge roller conveyor. Capacity: Max. 9,500 pieces.
Technical data: Power supply: 277/480 Volt and 60Hz Current: 5 A; Fuse protection: 3 x 25°. Filling dimensions: The filling consists of 3 parts that are independent: Part 1: Feeding roller conveyor with table for manual removal of Tyvek . Dimensions: 110 cm length, 80.5 cm width, 112 cm table top height. Removable feet. Removable feed track 150 cm long. Part 2: The basic machine is 190 cm long and 79 cm wide. The through conveyor belt is 137+186 cm long. Exit side projection 100 cm. The belt is completely off the table. The drive for this is at the exit end. Plug-in power supply. Part 3: The roller conveyor is 184 cm long. The dimensions are: Single cabinet 80 cm wide. Double cabinet 120 cm wide; 60 cm deep; 210 cm high.
Inspection machine for size bottles: 100 - 250 - 500 and 1000 ml
Dimensions of the containers : ø 49 mm, 100 ml; ø 66 mm, 250 ml; ø 78 mm, 500 ml; ø 95 mm, 1000ml
The machine speed (maximum and nominal) depends on the format: 100ml (max) 83 pieces / min, 5000 pieces / hour; 100ml (nominal) 67 pieces / min, 4000 pieces / hour
250ml (max.) 83 pieces / min, 5000 pieces / hour; 250ml (nominal) 60 pieces / min, 3600 pieces / hour
500 ml (max.) 67 pieces / min, 4000 pieces / hour; 500ml (nominal) 50pcs / min, 3000pcs / hour
1000ml (max.) 33 pieces / min, 2000 pieces / hour; 1000ml (nominal) 20 pieces / min, 12000 pieces / hour
Weight: mechanical module: 2100 kg, each turntable: 280 kg
Dimensions for transport (WxDxH): 1700x3050x2110Hmm
Minimum height from the floor: 150 mm ± 25 mm
Noise <75dB (A)
Supply voltage: 400V ± 10% 50 / 60Hz3Ph
SEPTRON® Line – Purified Water in the Smallest Area.
All preparation stages, from filtration to electrical demineralisation, are combined in a compact unit.
Up to 300 l/h Purifi ed Water in just 0.5 m2.
GAMP 4 conform operation with touch screen display for process visualisation.
Integrated cleaning programme.
Economical Purifi ed Water production from 150 to 300 l/h.
measurements: width 640 x height 930 x depth 715 mm
Operation with 230V/50Hz.
Mobile operating panel for optional wall mounting.
Guaranteed Purified Water quality acc. to Ph.Eur & USP (VAL version).
Short delivery time and start-up.
User friendly and low maintenance.
Faster Horizontal LAF transfer trolleys are used for the storage and the transfer of products that are sensitive to contamination, between two classified areas, generally separated by autoclaves.
Self powered mobile LAF Trolley: by means of dry UPS battery - provides a laminar air flow of Class ISO 5 (NF, EN, ISO 14644-1) , maintaining a constant positive pressure within the transfer trolley, thereby eliminating the possibility of any cross contamination.
Stainless steel structure AISI 304L 4B (Scotch Brite finishing) press-bent metal sheets with radius of 3 mm for easy cleaning and roughness lower than 0,8 Ra.
Filtration stages consisting of G3 pre-filter with typical arrestance of 80 ≤ Am > 90 according to EN 779 fitted on stainless steel cell with quick release system (no screws needed to remove the panel).
Low pressure drop H14 HEPA/ULPA filter according to CEN EN 1822.
Ventilation provided by energy efficiency low power consumption EBM Papst motorblower.
Dry battery UPS recovery pack with theoretical battery duration of 100 minutes starting from full charge status. UPS unit is provided with charge indicator (UPS must be plugged for recharging anytime in order to keep the always close to full charge status battery).
Pivoting castors with brakes.
Side, top and internal shelves made in stainless steel.
Frontal hinged or removable stainless steel panel with closing handle.
Backlit main switch.
preparation vessel for sterile with 1 chamber
volume 280 l
design pressure -1/4.1 bar (g)
test pressure 8.7 bar (g)
design temp. 80°C
burst disc 4.1 bar (g)
weight waterfilled 550 kg
weight empty 300 kg
purpose slurry
fluide group 2
category III
manufacturing number 5903-8250
Equipment: Reactor of 250 L
maximum allowable pressure C-I (bar) 3.5
maximum allowable pressure C-II (bar) n/A
max temperature permissible (° C) 150
temperature min. permissible (° C) 3
total volume (I.) 318
Group 2
Category N / A
Module A
Fully automated tube filler for cylindrical tablets.
It can be equipped with format parts for different tablets, tubes and caps. Changes from one format to another is
normally done within 30 minutes.
Format Rance:
Tube lenght: 55 - 180 mm
Tube Diameter: 19-35 mm
Tube material: Plastic or Aluminium
Tablet Diameter: 16-30 mm
Tablet Thickness: 3-10 mm
Machine Data:
Capacity: Nominal up to 60 tubes a minute or 60000 tablets an
hour, depending on the number of tablets per tube
Voltage: 3 x 400 V AC, zero and earth, 50 Hz
Power: Approx. 2 kW
Compressed air: 7-8 bar, approx. 500 L/minute
Weight: Approx. 400 kg
Bohle container mixer model PM 1000 with 900 kg payload.
This stainless steel mixer is designed for the gentle mixing of dry and powdery products. The system consists of a box girder with lifting device and mixing tool as well as the mixing container.
Mobile mixing containers are brushed on the inside, industrially ground on the outside, all weld seams are ground and the surface is colored.
The diameter is approx. 1,100 mm, the height of the container is 1,290 mm, which means a total volume of approx. 800 liters with a maximum payload of 900 kg.
1 Bohle bucket container is included in the set
The mixing container is moved manually under the container holder and the mixing tool is lowered into the container using the hand control.
The container is now attached to the box girder with 4 quick-release fasteners.
The mixing element, consisting of two slightly curved bodies, creates a counter-current of the product. The product itself does not spin. Each time the container is turned, the direction of flow changes twice (see version).
The speed and length of the mixing time can be pre-selected.
After the mixing process, the speed is automatically set to the minimum. The value is reduced and then remains in the basic position. After returning to the starting position, the mixing tool is raised and the container can be removed.
The system is controlled via a separate control panel. Mixing time and mixing speed can be preset, additional 9-digit batch input no. as well as a 2-digit product number. as well as identifiable people. An integrated printer is used for documentation.
High speed mixer from 1995 updated in 2007
including a 500 liter bin.
For the data you can put max load 1500 Kg
Electrical data 3N - 400V / 16A
Pressure 6 bar
Compressed air consumption 300 liters per minute
Leak test Nikka Densok model HDB II AS2.
The speed for 1 ml is 18.000 per hour .
The system automatically calulates the signal upper limit threshold of leak detection based on the good signal average (Auto Sensitivity).
Semi-automatic inspection machine for detection of particles and cosmetic defects
Adjustable high-precision rollers allow high speed rotation of ampules, vials and bottles, ranging from 0.5 ml to 1,000 ml in size, whirling up particulate matter in liquids. A glare-free system of concentrated light beams make any particulate matter more easily visible through the Tyndall effect. Light refracts off the particulate, making it glow like a small light bulb against a dark background.
Application:vials, infusion bottles
Range of sizes: 0.5 ml - 1,000 ml
Contents: clear solutions, suspensions, eye-drops, diagnostics, freeze dried products,sterile powder
Inspection criteria: particulate matter, glass and cosmetic defects, closure quality
Inspection area: overall glass surface, neck-, bottom-, shoulder area and crimping of vials, or ampule tips can be inspected 100 %
Operators: one per cabine machine dual with 2 stations
Technical output: max. 9000 objects/h/lane=>max. 150 objects/min/lane (actual output depends on operator’s performance)
Machine base: stainless steel frame and panels
Mode of operation: continuous or intermittent (switch)
Voltage: 230 V, 0.8-1.4 kW, 50 Hz standard
Inclination of objects: 60°
Tyndall lights: from 5 different directions with adjustable intensity, depending on products
Background: black, white, illuminated, polarized
Reject system: contactless with electronic reject unit
Working height: 900 mm ± 50 mm
Weight: ca. 550 kg net.
Via XXV Aprile, 8
21054 Fagnano Olona (VA)
Italia
Tel. +39 0331 1693557
email: inti@intisrl.it