The PMA System comprises of three machines. It is the ultimate in versatility, with modular options for blending, high shear granulating and melt or wet pelletizing. The design maximizes product processing and contained handling. User-selected standard process modules are combined with advanced automation and cleaning-in-place (CIP) systems.
GEA Niro Pharma Systems Aeromatic Fielder mixing/drying system consisting of:
(1) GEA Niro Aeromatic Fielder high shear mixer, type PMA 1200.
Polished stainless steel construction,
Total capacity 42.37 cu ft (1200 liter), working capacity 31.78 cu ft (900 liter).
Measurements : 4’9” (1500 mm) , x 2’36” (725 mm)
1 Chopper. Lit with counter weight. On stand. Siemens control panel., year 2008. incl. integrated
For high shear pelletization, a special mixing tool is available to optimize the process and maximise the output.
Wet Pelletizing: This process uses a rotary atomizer spray to achieve excellent dispersion of binder liquid through the mix, and a special high-speed rotation blade for maximum movement of the product, for more efficient pelletization. A PTFE container-lining minimizes the need for ‘top and tailing’, even with the most cohesive of products. Studies have shown that the PTFE liner, unique to GEA can increase production efficiency by as much as 40%. Alternatively, an extruder may be used, similar to those used for the manufacture of pellets. In a typical set-up all ingredients are pre-blended in a container after dispensing. Depending on the extruder design the liquid can be added in the extruder or mixed separately to the correct consistency. The material produced by the extruder is now transferred directly into a continuous fluid bed where it is dried to the desired moisture level.
Melt Pelletizing: This is an exceptionally fast method of producing pellets in a single step. The active material and binder are mixed in binder form then heated until the binder melts. A single batch is processed typically in just 15-20 minutes, and needs no further drying.
(2) GEA cone mill,
(3) GEA Niro fluid bed dryer, type Sirocco 1200,
Working capacity 958 liter,
Rated for 150 PSI (10 bar), year 2008. Incl. controls. Include Cip System , explosions Valves included
Complete Line composed by :
- BLISTER MACHINE FOR AMPOULES FARCON FC320 WITH VISION SYSTEM SEA
VISION AND DIFFERENT FORMATS INCLUDE
- CARTONER CAM MODEL HV2 FOR AMPOULES
- CHECK WEIGHER INLINE
- MARCHESINI BOX MARKING MACHINE MODEL MS734 FROM 2008
- WRAPPING MACHINE PRB MARCHESINI FAR 2001 FROM 2004
- CASE PACKER PRB MARCHESINI MODEL SP FROM 2004
- PALETTIZER PRB MARCHESINI MINISTRATUS YEAR 2009
BLISTER MACHINE FOR AMPOULES FARCON FC320 WITH VISION SYSTEM SEA VISION AND DIFFERENT FORMATS INCLUDE Manufacturer: Farcon ( MARCHESINI GROUP ) Model: FC320 Year : 2002 For thermoforming trays for ampoules, vials, Maximum forming depth : 42 mm Speed : 45 cycles/min Maximum forming area: Film width 254 mm; Film pitch 220 mm Maximum cutting area: Film width 248 mm; Film pitch 210 mm Maximum production: 63000 ampoules (1 ml)/h Autmomatic ampoules feeder on trays pick and place system to pick up trays and place them on a conveyor Two-way conveyor Pneumatic network : - Pressure: 6 to 8 bar, - Connection: Ø 3/4". - Consumption: 500 Nl/min Hydraulic network : - Pressure : 1.5 to 2 bars - Connection : Ø 1/2" Gas - Temperature : 11°C to 15°C - Average consumption : 200 l/h Power supply : 400V 3-phase, 50Hz, 3A Power : 6kVA CARTONER CAM MODEL HV2 FOR AMPOULES : Model HV2 Year 2002 GUK leaflet folder Laetus Argus 4 bar code reader Material of machinable cases: Compact carton with a weight of 220 +/- 400 gr / m2. Cords and preattached cases. Closure: With hot melt Automatic ampoules trays feeder . Electrical Trifase altering 220 or 380 V 50Hz Motor power 3 Kw Motor power bovine pump 1.25 Kw Power transformer and service circuits 0.95 Kw Total power 5.20 Kw Air consumption Absorbed 17NL per minute at a pressure of 6 bar CHECK WEIGHER INLINE PRODUCER RAMSEY TECNO EUROPA YEAR 2000 Belt with air reject system. Includes gripper belts at feed. Complete with control panel WRAPPING MACHINE PRB MARCHESINI FAR 2001 wrapping machine prb marchesini far 2001 from 2004 automatic over wrapper equipment: 100 mm wide x 1200 mm long dual side pvc belt conveyor pushing station wrapping station sealing station folding station driven by variable speed safety guards pack capacity: pack dimensions: length: min. 60 mm - max. 210 mm width min. 60 mm - max. 250 mm height: min. 10 mm - max. 150 mm maximum output: 80 packs/minute power: 2,5 kw CASE PACKER PRB MARCHESINI MODEL SP Year 2004 Automatic Horizontal Case Packer, machine for the final packaging in cardboard, made in a way to ensure reliability, versatility and space saving. A really small size equipment with high production features. MAIN FEATURES: This is an automatic unit able to perform automatically and in a continuous cycle the grouping of products, their introduction into shipping cartons previously taken from stock, formed and positioned in such a way as to enable the mobile hopper and the pusher to carry out the filling, which completed the two groups of transport side, which serve to maintain the correct squaring, convey the same to the exit by passing it through the operating groups which carry out the closure on both sides by tape closing . The entire machine is equipped with safety sensors and plexi-glass safety doors. This unit can be easily changed over for different types of products including boxes, bottles, tubs and containers, and different size boxes. Electrical panel with PLC. Level control of boxes in stock, maximum load in power control, counters (packagings, working hours, etc.). TECHNICAL DATA Power absorbed Kw 3,18 Electric Frequency Hz 50 Voltage Volt 380 Pressure bar 6 PRODUCTION CHARACTERISTICS Production 12 cycles/min Carton sized range : min ( AxBxC ) 20x10x 75 max 550 x 130 x 290 Case formats min-max (Length x Width x Height) mm 200x120x100 mm 550x350x350 ( 600 ) mm PALETTIZER PRB MARCHESINI MINISTRATUS Year 2009 Model Minustratus Max speed 10 cycles per minute Format range A 150 - 600 mm B 100 - 400 mm C 80 - 610 mm Dimension pallet height Standard dimension 1665 Pallet dimension 800 x 1200 / 1000 x 1200 Electrical details 380-220V 50Hz Power installed 6 kW Air compress 6 bar Air consumption 0,7 NL/ per cycle
Uhlmann 1030 Alu/Alu blister line with Uhlmann C130 cartoner
YEAR : 2000/ 2003
composed of
1) 2000 Uhlmann 1030 thermoforming machine
Max. speed: 600 blisters/ min
Maximum forming dimensions: 144 x 255 mm
Equipped with a Visiochrom HR20 camera from 2011
2) Uhlmann C130 cartoner from 2003
Max carton dimensions (A x B x H): 100 x 85 x 150 mm
Max. output: 150 cartons/min.
Some spare parts available with the line
Description :
• Washer + Tunnel + Filler for R&D scale-up or small production.
• Built date: 2008
• Running Time : 231 Hours Only.
• All documentation available ( Technical – FAT – SAT etc ).
Composed by:
1. Washer Model : Steriline RA-V2 -
2. Sterilizing Tunnel Model : Steriline STC20 -
3. Filler : Groninger. Model KFVG 251. – .
4. Available Formats : 2R,6R,10R,20R and 50H
COMPLETE SYRINGE FILLING LINE OPTIMA GROUPS • 2007
1. Debugger machine Bausch&stroebel model LFO 9060 from 2012
2. Belt under laminar flow Optima Inova
3. Robot for Tyvek removal Optima Inova model TRR •
4. Filling machine Optima Inova model H6-10
5. denester machine Optima Inova model SH260
6. inspection machine Brevetti Cea model k15\600 •
7. Renester machine Optima Inova model SN260 •
Syringes diameter 10.85
speed 400 pz\min
1)Ampoule filler under isolator
Producer : Bosch
Model : ALK 4080
Year of manufacture : 1997
Production : 400 ampoules per minute working range
Diameter : From 9 up to 18 mm
Height : From 60 up to 110 mm
Formats incluided : 1 - 2 -5 - 10 ml ( to be confirmed )
The machine comes with ISOLATOR and DEDICATE AHU
2) Depyrogenation owen for ampoules Bosch Producer : Bosch Model : HQL 3420
Year : 1997
Production : 24.000 ampoules of 1 ml per hour
HQL facilities are ideal for vial sterilization.
This model is exceptional due to the lack of passage in the tunnel, which is the result of the laminar hot air flow process with its high degree of efficiency. Sterilization tunnels are used in pharmaceutical industry filling lines to sterilize glass containers before aseptically filling them.
These tunnels use forced air at temperatures up to 350 ° C.
Bosch HQL drying and sterilization tunnels operate with unidirectional flow, with process curves of temperature progression and significantly reduced sterilization times.
They guarantee the consistent precision necessary for validation, qualification, and reliable production capacity.
Through a filter, the make-up air is introduced into the tunnel.
Inside the tunnel, the air, drawn in by the fans, feeds the supply and cooling section through the pre-filters and the air particle filters in the separate areas of the tunnel.
Using the laminar flow principle, the air flow is directed vertically in the containers.
Below the conveyor, the air is directed back through a recirculation duct to the fan.
The fans need fresh air for the heating section: laminar flow unit.
The heating elements in the recirculation duct serve to heat the recirculation air to the preset temperature.
Below the particulate air filters are heating elements that are output to a recording and temperature control device.
The cooling section works with laminar flow. A fan in the cooling section draws the hot air under the conveyor belt.
The volume of exhaust air is adjusted automatically.
The tunnel is equipped with an automatic overpressure control in the cooling section.
Modular system for tunnel assembly suitable for the required power range with optimal energy consumption. Construction according to GMP. Compatible container transport systems for stable and non-stable containers. Safe conveyor belts on the floor and side levels operated simultaneously. Excellent accessibility and ease of operation.
Ampoule washing machine with different washing cicles
(water WFI - sterile air )
Producer : Bosch
Model :RRU 3082
Year of manufacturing :1997
Production : 400 ampoules per minute
Working range : Diameter : 9 - 18 mm
Height : 60 - 110 mm
Formats included : 1 -2 - 5 - 10 ml ( to be verified )
The Bosch RRU series of washers and dryers perform ultrasonic cleaning for fast and accurate removal of particulate matter.
Its swivel design allows for a small footprint and ease of operation with fast and accurate removal of particulate matter and reliable feeding of small containers. RRU Bosch rotary heads will give you excellent results with gentle vial handling. They can be configured for a wide range of formats.
Rotary washer ideal for cleaning vial bottles.
Exceptional for its optimal accessibility, for example, and it is very easy to use. Processing ranges and capacities depend on individual containers, line integration, etc.
Construction according to GMP; reduced size; safe transport of containers; high level of ultrasonic cleaning; stations for internal and external container washing; with the pumping station; fast format change.
COLOR RING PRINTER BOSCH DRN 3010
This high-speed machine is design to mark ampoules with single or multiple ring codes.
It is useful for identifying trial batches or for adding colour codes to standard batches of Ampoules for identification purposes or to avoid intermixing of batches.
• Included format sets 1 ml - 2 ml - 5 ml- 10 ml To be verified
Complete line for ampoule Bosch 24.000 per hour with Isolator from 2009 Composed of :
1) Ampoule filler under isolator
2) Depyrogenation owen for ampoules Bosch
3) Ampoule washing machine with different washing cicles
4)Air Handling Unit
1-Ampoule filler under isolator • Producer : Bosch • Model : ALF 4080 Year of manufacture : 2009 • Production : 400 ampoules per minute working range • Diameter : From 9 up to 30 mm • Height : From 60 up to 160 mm • Formats incluided :1 - 2ml • The machine comes with ISOLATOR and DEDICATE AHU AND CIP/ SIP IPC ( weigh control ampoules ) • The ALF series of machines meets all the prerequisites for modern ampoule production. The convincing line concept. • Wide experience, state-of-the-art know- how, highly developed engineering and Bosch quality – new dimensions for dependability, economy and flexibility with easy operator control. • The ALF series was configured in accordance with pathfinding, pharmaceutically compliant findings to provide a modern, ergonomic design that supplies the customer with maximum benefits. Decisive in this design is a basic ma-chine that can be equipped and retrofitted with various equipment units. These include: • In-process control system • Infeed and outfeed starwheel • Isolator version Work and production considerations: • Easy operator control due to the slim, tidy, clearly laid-out construction Easy cleaning. • All machine functions can be overseen, controlled and operated from one position at the front. • Clean Room compliance. • Drive and production segments are clearly separated: worktop right through. • The ampoules are transferred directly from the sterilizing tunnel to the ALF infeed belt. • Via a scroll conveyor and transfer wheel the ampoules reach the conveying system by means of which they are con-ducted through the work stations: gasflushing, filling, sealing. • Each filling point controls individually contactless scanning of the ampoule necks – "no ampoule – no filling". The ampoule necks are precentred by the draw-off grippers, the ampoule tips are then grasped and fed into a collection container. • During the sealing procedure post-gasflushing can take place. The filled and sealed ampoules are pushed virtually load-free into the outfeed magazine. Rotary slide pumps: • Bosch provides precision filling for parente- ralia with its proven rotary slide pump. Product- conserving and drip-free filling to the highest degree of filling precision are ensured for a wide range of different properties. • Bosch seal-free rotary slide pumps have easy vertical cleaning paths. Technical in the lead: • 3-part: rotary slide valve, pump cylinder,Pump piston. • Seal free. • Easy, vertical cleaning paths. ❒ • CIP/SIP capability. 2) Depyrogenation owen for ampoules Bosch Producer : Bosch Model : HQL 2440S Year : 2009 Production : 24.000 ampoules of 1 ml per hour HQL facilities are ideal for vial sterilization. This model is exceptional due to the lack of passage in the tunnel, which is the result of the laminar hot air flow process with its high degree of efficiency. Sterilization tunnels are used in pharmaceutical industry filling lines to sterilize glass containers before aseptically filling them. These tunnels use forced air at temperatures up to 350 °C. Bosch HQL drying and sterilization tunnels operate with unidirectional flow, with process curves of temperature progression and significantly reduced sterilization times. They guarantee the consistent precision necessary for validation, qualification, and reliable production capacity. Through a filter, the make-up air is introduced into the tunnel. Inside the tunnel, the air, drawn in by the fans, feeds the supply and cooling section through the pre-filters and the air particle filters in the separate areas of the tunnel. Using the laminar flow principle, the air flow is directed vertically in the containers. Below the conveyor, the air is directed back through a recirculation duct to the fan. The fans need fresh air for the heating section: laminar flow unit. The heating elements in the recirculation duct serve to heat the recirculation air to the preset temperature. Below the particulate air filters are heating elements that are output to a recording and temperature control device. The cooling section works with laminar flow. A fan in the cooling section draws the hot air under the conveyor belt. The volume of exhaust air is adjusted automatically. The tunnel is equipped with an automatic overpressure control in the cooling section. Modular system for tunnel assembly suitable for the required power range with optimal energy consumption. Construction according to GMP. Compatible container transport systems for stable and non-stable containers. Safe conveyor belts on the floor and side levels operated simultaneously. Excellent accessibility and ease of operation. 3) Ampoule washing machine with different washing cicles (water WFI - sterile air ) Producer : Bosch Model :RRU 3084 Year of manufacturing :2009 Production : 400 ampoules per minute Working range : Diameter : 9 - 30 mm Height : 60 - 145 mm Formats included : 1 -2 ml The Bosch RRU series of washers and dryers perform ultrasonic cleaning for fast and accurate removal of particulate matter. Its swivel design allows for a small footprint and ease of operation with fast and accurate removal of particulate matter and reliable feeding of small containers. RRU Bosch rotary heads will give you excellent results with gentle vial handling. They can be configured for a wide range of formats. Rotary washer ideal for cleaning vial bottles. Exceptional for its optimal accessibility, for example, and it is very easy to use. Processing ranges and capacities depend on individual containers, line integration, etc. Construction according to GMP; reduced size; safe transport of containers; high level of ultrasonic cleaning; stations for internal and external container washing; with the pumping station; fast format change.
bosch complete line for vials composed of:
1. WASHING MACHINE MODEL RRU 2020 The Bosch RRU series of washers and dryers performs ultrasonic cleaning for fast and precise removal of particulate and precise removal of particulate material. The rotary design allows for a small footprint and ease of footprint and ease of operation with fast and accurate removal of particulate material and reliable feeding of small containers. Bosch RRU rotary heads will give you excellent results with gentle handling of vials. They can be configured for a wide range of formats. Ideal rotary washer for cleaning vial bottles. Processing ranges and capacities depend on individual containers, line integration on individual containers, line integration, etc. GMP-compliant construction; small footprint; safe transport of containers; high level of ultrasonic cleaning; stations for internal and external container washing external and internal container washing stations; with pumping station; quick format changeover.
TECHNICAL SPECIFICATIONS
Net weight Kg 1790
Maximum container diameter 52 mm
Maximum container height 110 mm
Maximum output 8000 / hour
2. DEPYROGENATION TUNNEL BOSCH HQL 3240 HQL installations are ideal for the sterilisation of vials. This model is exceptional because of the low throughput in the tunnel, which is the result of the laminar hot air flow process with its high degree of efficiency. Sterilisation tunnels are used on filling lines in the pharmaceutical industry to sterilise glass containers prior to aseptic filling. These tunnels use forced air at temperatures of up to 350°C. Bosch HQL drying and sterilisation tunnels operate with unidirectional flow, with process curves of temperature progression and significantly reduced sterilisation times. They guarantee the constant precision required for validation, qualification and reliable production capability. Through a filter, make-up air is introduced into the tunnel. Inside the tunnel, the air, drawn in by fans, feeds the supply and cooling section through pre-filters and particulate air filters in separate areas of the tunnel. Using the laminar flow principle, the air flow is directed vertically into the containers. Underneath the conveyor belt, the air is directed back through a recirculation duct to the fan. The fans need fresh air for the heating section: laminar flow unit. The heating elements in the recirculation duct serve to heat the recirculation air to the preset temperature. Below the particulate air filters there are heating elements with an outlet to a temperature control and recording device. The cooling section operates with laminar flow. A fan in the cooling section exhausts the hot air under the conveyor belt. The exhaust air volume is automatically adjusted. The tunnel is equipped with an automatic overpressure control in the cooling section. Modular system for tunnel assembly suitable for the required power range with optimum energy consumption. GMP-compliant construction. Compatible container transport systems for stable and unstable containers. Safe conveyor belts on floor and side levels operated simultaneously. Excellent accessibility and ease of operation. Technical data
Length 2865 mm
Width mm 2200
Height 2630 mm
Weight Kg 2500
3. Bosch MLF 3002 intermittent motion filling and closing machine for injectable vials. Includes rotaty table for empty vials, 4 rotary piston filling heads (currently filling 100ml), stoppering inserter with bowl feeder, and closing system for ALU caps with bowl feeder. 90 degree reject to the rear of the machine, and product discharge in line with product flow. Suitable for containers up to 55mm diameter and up to 185mm high (double index), inserts and caps up to 36mm diameter.
Output approximately 6,000 containers per hour.
Complete line counting and sealing bottles
1 - BOTTLE POSITIONER UNSCRAMBLER : https://intimac.it/en/used-machines/reorganisers/reorganisers-bcm-engineering-bcm-500-120-/ 2 - BLOW OUT ROMACO AIRJET 3000 : https://intimac.it/en/used-machines/washing-machines-for-ampoules-and-vials-blowing-table-for-bottles/washing-machines-for-ampoules-and-vials-blowing-table-for-bottles-romaco-airjet-3000-/
3 - IMA SV2 TABLET COUNTING : https://intimac.it/en/used-machines/counting-machines-for-tablet-and-capsules/counting-machines-for-tablet-and-capsules-ima-swiftpack-automation-sv2-12-efs-twin/
4 - IMA LIBRA F550 : https://intimac.it/en/used-machines/counting-machines-for-tablet-and-capsules/counting-machines-for-tablet-and-capsules-ima-libra-f550/
5 - IMA SWIFTPACK INDUCTION + SEALER : https://intimac.it/en/used-machines/capping-and-closing-machines/capping-and-closing-machines-ima-swiftpack-automation-ilsp/
1: https://intimac.it/en/used-machines/washing-machines-for-ampoules-and-vials-blowing-table-for-bottles/washing-machines-for-ampoules-and-vials-blowing-table-for-bottles-gf-gfwm6/
2: https://intimac.it/en/used-machines/autoclaves-sterilizing-ovens-freeze-dryers/autoclaves-sterilizing-ovens-freeze-dryers-steriline-st-0/
3: https://intimac.it/en/used-machines/aseptic-filling-and-closing-machines/aseptic-filling-and-closing-machines-gf-afm12000/
4: https://intimac.it/en/used-machines/aseptic-filling-and-closing-machines/aseptic-filling-and-closing-machines-gf-vfcsm-10000/
5. https://intimac.it/en/used-machines/capping-and-closing-machines/capping-and-closing-machines-gf-vfcsm-10000/
https://intimac.it/en/used-machines/cartoning-machines-case-packers/facf1b-cartoning-machines-case-packers-marchesini-group-ba400/
https://intimac.it/en/used-machines/blistering-machines/blistering-machines-marchesini-group-mb421/
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Italia
Tel. +39 0331 1693557
email: inti@intisrl.it